PARACOCCIDIOIDOMICOSE: DESAFIOS PARA O ENFRENTAMENTO DE UMA DOENÇA NEGLIGENCIADA

Autores

  • Mariana Barbosa Lopes
  • Diego Bezerra Soares
  • Gabriele Pereira Dos Reis
  • Fabiola Julianne Alves De Pinho
  • Isabela Reis Manzoli

DOI:

https://doi.org/10.51161/rems/2249

Palavras-chave:

DESAFIOS, DIAGNÓSTICO, PARACOCCIDIOIDOMICOSE, POPULAÇÃO NEGLIGENCIADA

Resumo

Introdução: A Paracoccidioidomicose (PCM) é uma micose sistêmica causada pela inalação ou por inoculação de esporos de fungos dimórficos do gênero Paracoccidioides. Essa doença, na fase aguda, afeta a mucosa das vias aéreas superiores, a boca, a pele e órgãos internos, podendo evoluir para a forma crônica disseminada pela via linfática, hematogênica ou canalicular. Em relação ao perfil epidemiológico, observa-se que residentes e trabalhadores da zona rural fazem parte da principal população acometida, uma vez que a produção de esporos infectantes ocorre no solo e em detritos vegetais. Ademais, tal infecção fúngica é considerada como a décima causa de morbimortalidade dentre as doenças endêmicas parasitárias no Brasil e apresenta um recente aumento no número de casos. Nesse contexto, apesar de ser uma enfermidade que pode levar a graves complicações, a paracoccidioidomicose é uma doença tropical negligenciada por afetar uma população que vive em condições de vulnerabilidade social. Objetivo: Devido à falta de visibilidade da PCM, faz-se necessário o aprimoramento da análise epidemiológica da doença no país. Sob esse viés, foi levantado o seguinte questionamento: “Quais os principais desafios na prevenção e no tratamento da paracoccidioidomicose?”. Material e métodos: O estudo consiste em uma revisão de literatura retrospectiva com o intuito de elucidar os aspectos determinantes para a detecção precoce, a redução do número de casos e promover um melhor prognóstico. Para tanto, utilizou-se as bases de dados SciELO, PubMed e MedLine. Resultados: A partir dessa análise, foi possível evidenciar a importância médica e social da paracoccidioidomicose. Entretanto, não recebe o investimento adequado das instituições envolvidas em políticas de saúde pública. Diante disso, um dos principais desafios enfrentados está na acessibilidade ao diagnóstico precoce e a falta da notificação compulsória, uma vez que essa doença acomete uma população negligenciada. Conclusão: Em síntese, nota-se uma dificuldade nas abordagens terapêuticas para a PCM, já que há desinteresse da indústria farmacêutica no que diz respeito ao desenvolvimento de novos antifúngicos, comprometendo a eficácia e adesão ao tratamento.

Publicado

2021-10-08

Como Citar

Lopes, M. B. ., Soares, D. B. ., Reis, G. P. D. ., Pinho, F. J. A. D. ., & Manzoli, I. R. . (2021). PARACOCCIDIOIDOMICOSE: DESAFIOS PARA O ENFRENTAMENTO DE UMA DOENÇA NEGLIGENCIADA. Revista Multidisciplinar Em Saúde, 2(4), 105. https://doi.org/10.51161/rems/2249

Edição

Seção

I Congresso Brasileiro de Doenças Infectocontagiosas On-line
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php
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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php
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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php
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                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php
                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
                                                               DAO.retrieveCached(SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2], 3600) % line   91, file: ArticleSearchDAO.inc.php
                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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