HANSENÍASE: ASPECTOS IMUNOLÓGICOS E PATOGÊNICOS

Diego Bezerra  Soares; Isabela Reis  Manzoli; Lohraine Talia  Domingues; Paulo Schumann  Neto

doi:10.51161/rems/2239

HANSENÍASE: ASPECTOS IMUNOLÓGICOS E PATOGÊNICOS

Autores

Diego Bezerra Soares
Isabela Reis Manzoli
Lohraine Talia Domingues
Paulo Schumann Neto

DOI:

https://doi.org/10.51161/rems/2239

Palavras-chave:

HANSENÍASE, IMUNOLOGIA, PATOGENICIDADE

Resumo

Introdução: A Hanseníase é uma doença infecciosa causada pela bactéria Mycobacterium leprae que acomete principalmente a pele e nervos periféricos. Ademais, a transmissão desse bacilo ocorre através do aparelho respiratório superior por meio de secreções nasais e de gotículas, no entanto, cerca de 5% dos indivíduos expostos são acometidos, por fatores genéticos. Outrossim, essa patologia caracteriza-se pelo comprometimento de áreas da pele com manchas avermelhadas ou brancas, perda da sensibilidade, dor e tato. Além disso, sabe-se que o Brasil é considerado o país com maior incidência da doença no mundo. Objetivo: Devido ao elevado número de casos por habitante, faz-se necessário mais estudos que esclareçam os mecanismos imunológicos e a padronização dessa patologia. Dessa forma, foi levantado o seguinte questionamento: “Como ocorrem os fatores imunológicos de patogenicidade da Hanseníase? ”. Metodologia: A pesquisa consiste em uma revisão de literatura retrospectiva, com o objetivo de elucidar os aspectos imunológicos envolvidos na patogenicidade da Hanseníase. Para tanto, utilizou-se a base de dados Pubmed, Medline e SciELO. Resultados: A partir desse estudo foi possível observar que os macrófagos exercem papel fundamental na patogenicidade do parasita, uma vez que são os principais hospedeiros dos bacilos. A penetração nos macrófagos constitui um importante mecanismo de ação, já que o Mycobacterium leprae induz um quadro de escassez de linfócitos buscando evitar uma resposta imunológica acentuada, favorecendo assim, sua disseminação. Sob esse viés, em situações em que os macrófagos estão repletos de bacilos há desenvolvimento do quadro clínico mais grave da doença, a forma virchowiana. Conclusão: Por meio desse estudo, notou-se que os fatores imunológicos estão relacionados a patogenicidade da doença influenciando tanto no agravamento da forma clínica quanto ao não desenvolvimento da patologia. Haja vista que uma resposta imune efetiva em combinação com a baixa virulência do Mycobacterium leprae está associada à resistência para o surgimento da Hanseníase.

Publicado

2021-10-08

Como Citar

Soares , D. B. ., Manzoli, I. R. ., Domingues, L. T. ., & Neto, P. S. . (2021). HANSENÍASE: ASPECTOS IMUNOLÓGICOS E PATOGÊNICOS. Revista Multidisciplinar Em Saúde, 2(4), 95. https://doi.org/10.51161/rems/2239

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

I Congresso Brasileiro de Doenças Infectocontagiosas On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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