DESREGULAÇÃO DA CÉLULA DENDRÍTICA NA COVID-19: UMA REVISÃO LITERÁRIA

Giovanna Rolim Pinheiro Lima; Beatriz Vieira Loiola Coutinho; Pedro Quaranta Alves Cavalcanti; Raul Sancho De Carvalho Rocha; Silvia Fernandes Ribeiro Da Silva

doi:10.51161/rems/985

DESREGULAÇÃO DA CÉLULA DENDRÍTICA NA COVID-19: UMA REVISÃO LITERÁRIA

Autores

Giovanna Rolim Pinheiro Lima
Beatriz Vieira Loiola Coutinho
Pedro Quaranta Alves Cavalcanti
Raul Sancho De Carvalho Rocha
Silvia Fernandes Ribeiro Da Silva

DOI:

https://doi.org/10.51161/rems/985

Palavras-chave:

Célula Dendrítica, Covid-19, Imunidade Celular, Sars-cov 2

Resumo

Introdução- As células dendríticas (CDs) são células apresentadoras de antígenos, consideradas mensageiras cruciais entre a imunidade inata e a adaptativa, possuindo papel central na defesa contra patógenos intracelulares. Em geral, a CD após capturar o vírus migra para os órgãos linfoides secundários, onde apresenta peptídeos e participa da diferenciação de linfócitos T. Acredita-se que o comprometimento da resposta efetiva dos linfócitos T está associada a disfunção das CDs na COVID-19. Objetivo- Avaliar a consequência da desregulação da CD na COVID-19. Material e métodos- Foi realizado levantamento bibliográfico do período de 2020 e 2021 na base de dados da PubMed. Utilizou-se as palavras-chave “COVID-19”, “SARS-CoV-2” e “dendritic cells”. Foram excluídos artigos que não se referiam à participação da CD em casos graves de COVID-19. Somente 6 artigos abordaram o tema de forma satisfatória, sendo assim selecionados. Resultados- As CDs são amplamente distribuídas no trato respiratório, onde atuam como importantes sentinelas, mas também são alvos de infecções pelo SARS-CoV-2. Autópsias pós-morte de pacientes com COVID-19 mostraram que o SARS-CoV-2 acarreta morte celular em órgãos linfoides secundários, o que pode comprometer a apresentação antigênica. Foi relatado que o SARS-CoV-2 é capaz de ficar em estado de latência nas CDs, o que impossibilita a sua ativação e expressão de moléculas coestimuladoras, prejudicando a apresentação de peptídeos aos linfócitos T, como também a geração de linfócitos Th1, ocasionando uma redução da resposta imune celular e pior prognóstico. Além disso, o SARS-CoV-2 pode desregular a CD, estimulando a produção de grandes quantidades de citocinas pró-inflamatórias (TNF-α, IL-6 e IL-8), chamada de tempestade de citocinas que, associada a uma resposta anti-viral inadequada, contribui para a inflamação exacerbada observada na COVID grave. Por outro lado, foi mostrado uma correlação entre a ativação de CDs por trombina-PAR-1 e a hipercoagulabilidade em casos graves da COVID-19. Conclusão- As CDs dendríticas possuem papel crucial na imunidade celular e no bom prognóstico da COVID-19. Porém, a sua disfunção, induzida pelo SARS-CoV-2, pode comprometer a resposta de linfócitos T e exacerbar a inflamação. Faz-se necessário a realização de mais estudos acerca da correlação dessa disfunção com o pior prognóstico da COVID.

Publicado

2021-04-24

Como Citar

Lima, G. R. P., Coutinho, B. V. L., Cavalcanti, P. Q. A., Rocha, R. S. D. C., & Da Silva, S. F. R. (2021). DESREGULAÇÃO DA CÉLULA DENDRÍTICA NA COVID-19: UMA REVISÃO LITERÁRIA. Revista Multidisciplinar Em Saúde, 2(2), 43. https://doi.org/10.51161/rems/985

Baixar Citação

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Imunologia On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
                                                               DAO.retrieveCached(SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2], 3600) % line   91, file: ArticleSearchDAO.inc.php
                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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