COVID-19 E COINFECÇÃO POR ASPERGILLUS SPP: UMA REVISÃO LITERÁRIA

Pedro Quaranta Alves  Cavalcanti; Giovanna Rolim Pinheiro Lima; Beatriz Vieira Loiola  Coutinho; Idna Lara Goes De  Sena; Silvia Fernandes Ribeiro Da  Silva

doi:10.51161/rems/1162

COVID-19 E COINFECÇÃO POR ASPERGILLUS SPP: UMA REVISÃO LITERÁRIA

Autores

Pedro Quaranta Alves Cavalcanti
Giovanna Rolim Pinheiro Lima
Beatriz Vieira Loiola Coutinho
Idna Lara Goes De Sena
Silvia Fernandes Ribeiro Da Silva

DOI:

https://doi.org/10.51161/rems/1162

Palavras-chave:

COVID-19, ASPERGILOSE PULMONAR INVASIVA, COINFECÇÃO, ASPERGILLUS

Resumo

Introdução: A Aspergilose Pulmonar Invasiva (API), ocasionada pelo fungo Aspergillus spp, é uma doença de elevada morbimortalidade em pacientes com comprometimento do sistema imunológico. Estudos têm mostrado o risco de pacientes com COVID-19 desenvolver coinfecção por Aspergillus spp. Objetivos: Avaliar a consequência da infecção pelo Aspergillus spp na COVID-19. Material e métodos: Foi realizado levantamento bibliográfico do período de 2020 e 2021 na base de dados da PubMed. Utilizou-se as palavras-chave “Aspergillus” e “COVID-19”. Foram selecionados 5 artigos que abordaram o tema de forma satisfatória. Resultados: O relato de coinfecções na COVID-19 por bactérias e fungos tem se tornado cada vez mais frequente e aumentado a preocupação dos pesquisadores no mundo. A coinfecção por Aspergillus spp é um fator de risco que dificulta o diagnóstico, prognóstico, tratamento, agrava os sintomas e eleva a taxa de mortalidade de pacientes com COVID-19 grave. A coinfecção por Aspergillus, com consequente desenvolvimento de API, foi associada a casos de COVID-19 grave. Dos pacientes (5%) que evoluíram para a COVID-19 grave e necessitaram de cuidados intensivos, 19% a 34% deles desenvolveram API. Acredita-se que a COVID-19 aumenta a susceptibilidade da infecção por Aspergillus spp devido: ao excesso de antibióticos usado no seu tratamento; a imunomodulação do sistema imune; uso de Tocilizumab®; da hiperinflamação e da tempestade de citocinas; a ativação dos linfócitos Th2; níveis séricos elevados de IL-6 e IL-10; e diminuição da resposta via linfócito Th1. A coinfecção por Aspergillus spp pode influenciar no grau de inflamação sistêmica e na progressão e prognóstico da COVID-19, com consequente aumento de cuidados intensivos, de óbitos ou estender o tempo de internação e cura da COVID-19. Além disso, a coinfecção e o uso prolongado de antibióticos no tratamento da COVID-19 podem alterar a homeostase intestinal, intensificando a infecção, pois o desequilíbrio da microbiota, nos casos de infecções fúngicas, podem provocar alterações intestinais por até 12 dias após a não identificação do SARS-CoV-2 na nasofaringe. Conclusão: A API apresenta relevância clínica no contexto pandêmico atual devido a sua alta morbimortalidade na COVID-19 grave. Faz-se necessário mais estudos sobre a sua fisiopatologia que minimizem o agravamento da COVID-19.

Publicado

2021-06-11

Como Citar

Cavalcanti, P. Q. A. ., Lima, G. R. P., Coutinho, B. V. L., Sena, I. L. G. D., & Silva, S. F. R. D. (2021). COVID-19 E COINFECÇÃO POR ASPERGILLUS SPP: UMA REVISÃO LITERÁRIA. Revista Multidisciplinar Em Saúde, 2(2), 05. https://doi.org/10.51161/rems/1162

Baixar Citação

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do I Congresso Nacional de Microbiologia Clínica On-Line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
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                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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