TRATAMENTO DO CÂNCER DE MAMA TRIPLO NEGATIVO: O QUE DIZ A LITERATURA?

Maria Eduarda Granucci  Spolador; Maria Teresa  Vasconcelos; Pedro Henrique Gunha  Basílio; Samya Hamad  Mehanna; Victória Gayoso Neves  Pereira

doi:10.51161/rems/1581

TRATAMENTO DO CÂNCER DE MAMA TRIPLO NEGATIVO: O QUE DIZ A LITERATURA?

Autores

Maria Eduarda Granucci Spolador
Maria Teresa Vasconcelos
Pedro Henrique Gunha Basílio
Samya Hamad Mehanna
Victória Gayoso Neves Pereira

DOI:

https://doi.org/10.51161/rems/1581

Palavras-chave:

CÂNCER DE MAMA TRIPLO NEGATIVO, QUIMIOTERAPIA, TRANSPORTADORES ABC, TRATAMENTO

Resumo

Introdução: O câncer de mama triplo negativo (TNBC) caracteriza-se pela não expressão de receptores hormonais de estrogênio e progesterona, e negatividade do fator de crescimento epitelial humano 2 (HER2), correspondendo até 15% dos cânceres mamários. Este tipo molecular apresenta elevado índice proliferativo, sendo mais agressivo e capaz de produzir metástases e recidivas, apresentando pior prognóstico. O tratamento cirúrgico está indicado somado, principalmente, à quimioterapia. Objetivos: Identificar tratamentos atuais do TNBC e possíveis quimiorresistências. Material e métodos: Revisão bibliográfica de artigos da plataforma PubMed. Resultados: A quimioterapia neoadjuvante é usada para estágio inicial do TNBC, com altas taxas de resposta patológica completa (PCR). Entre os medicamentos utilizados, houve melhora na PCR das pacientes tratadas com paclitaxel semanalmente e quando adicionado carboplatina e/ou bevacizumabe houve acréscimo na taxa de PCR. Já para pacientes estágio II-III, o tratamento foi com paclitaxel semanalmente e doxorrubicina lipossomal não-peguilada, somado a bevacizumab ou trastuzumabe a cada 3 semanas, com/sem a adição semanal de carboplatina. A carboplatina adicional resulta em PCR mais frequentemente, porém há maior toxicidade. No tratamento adjuvante, recomendado para casos avançados ou metastáticos, relacionados à mutação BRCA ou resistência endócrina previamente tratados com antraciclina com/sem taxano, é indicado suplementar o regime com compostos de platina ou carboplatina, sendo que paclitaxel mostrou-se eficaz. Entre as justificativas para o subconjunto que apresenta resistência quimioterápica, correlaciona-se o efluxo de drogas mediado pelos transportadores de cassete de ligação de ATP (ABC), que utilizam ATP para efluir compostos através da membrana celular. Dentre os ABCs, destaque para proteína-1 multirresistente (ABCC1/MRP1) que teve sua expressão aumentada relacionada à neoadjuvância. Outros tratamentos incluem ainda imunoterapia e inibidores da enzima poliADP-ribose polimerase. Conclusão: Apesar dos avanços na terapêutica do TNBC, são necessárias pesquisas estabelecendo protocolos de tratamento otimizados, objetivando abordagens quimioterápicas personalizadas, resultando em melhores prognósticos aos pacientes.

Publicado

2021-07-28

Como Citar

Spolador , M. E. G. ., Vasconcelos, M. T. ., Basílio, P. H. G. ., Mehanna, S. H. ., & Pereira, V. G. N. . (2021). TRATAMENTO DO CÂNCER DE MAMA TRIPLO NEGATIVO: O QUE DIZ A LITERATURA?. Revista Multidisciplinar Em Saúde, 2(3), 49. https://doi.org/10.51161/rems/1581

Baixar Citação

Edição

v. 2 n. 3 (2021)

Seção

I Congresso Nacional Multidisciplinar de Oncologia On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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