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v. 2 n. 4 (2021)
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I Congresso On-line Nacional de Histologia e Embriologia Humana
HISTOPATOLOGIA DAS NEOPLASIAS INTRAEPITELIAIS CERVICAIS ASSOCIADAS AO PAPILOMAVÍRUS HUMANO
Autores
Maria Fernanda Brandão
Larissa Dayelle Osternack
Samya Hamad Mehanna
Palavras-chave:
DISPLASIA DO COLO DO ÚTERO, DOENÇAS DO COLO DO ÚTERO, INFECÇÕES POR PAPILLOMAVIRUS, LESÕES INTRAEPITELIAIS ESCAMOSAS CERVICAIS, NEOPLASIAS DO COLO DO ÚTERO
Resumo
Introdução: Neoplasias intraepiteliais cervicais (NICs) são lesões precursoras do carcinoma de células escamosas no colo uterino, categorizadas segundo a proporção epitelial afetada: baixo grau (NIC I), grau moderado (NIC II) e alto grau (NIC III), a última correspondendo ao carcinoma in situ . Infecções persistentes de subtipos oncogênicos de alto risco do papilomavírus humano (HPV) podem levar ao desenvolvimento das NICs, com potencial de progressão para câncer invasivo entre 10 e 20 anos. Objetivos: Descrever a histologia cervical, relacionada ao surgimento das NICs decorrentes da infecção pelo HPV. Material e Métodos: Pesquisa bibliográfica nas bases Pubmed e Scielo, utilizando descritores: “cervical cancer”, “cervical intraepithelial neoplasms” e “human papilloma virus”. Foram utilizados Robbins Patologia Básica 9ª Ed.; Junqueira e Carneiro Histologia Básica 12ª Ed. Resultados: A histologia do colo do útero apresenta poucas artérias espiraladas e grandes glândulas ramificadas, não sofre alterações significativas de espessura durante ciclos menstruais e possui três componentes. A ectocérvix se projeta para a vagina e possui epitélio estratificado pavimentoso não queratinizado. A endocérvix é revestida por tecido epitelial glandular colunar simples. Entre as duas regiões está a junção escamocolunar (JEC), ponto de mudança abrupta entre os epitélios. Após ectrópio, a JEC sofre metaplasia escamosa devido à irritação causada pela acidez vaginal, gerando a zona de transformação (ZT). Células-tronco de reserva sustentam a JEC, conduzem a metaplasia e são mais suscetíveis à infecção pelo HPV. A patogênese pelo HPV abrange infecção inicial na JEC que, se persistente, possibilita integração do genoma viral ao do hospedeiro. A expressão das oncoproteínas virais E6 e E7, somada à desregulação do ciclo celular, promove o desenvolvimento de displasia. A invasão do epitélio por subtipos de alto risco do HPV (16 e 18) é o principal fator no desenvolvimento das NICs e cânceres cervicais, seja escamoso ou adenocarcinoma. Ainda, condições genéticas, alimentares e ambientais são fatores de risco para desenvolvimento das NICs. A prevalência de HPV nos carcinomas cervicais pode alcançar 99,7%. Conclusão: As características morfológicas encontradas no colo uterino explicam sua relação com a infecção pelo HPV. Assim, destaca-se a importância do estudo desta histologia, possibilitando a compreensão da fisiopatogenia da doença.
Como Citar
Brandão, M. F., Osternack, L. D. ., & Mehanna, S. H. . (2021). HISTOPATOLOGIA DAS NEOPLASIAS INTRAEPITELIAIS CERVICAIS ASSOCIADAS AO PAPILOMAVÍRUS HUMANO. Revista Multidisciplinar Em Saúde , 2 (4), 15. https://doi.org/10.51161/rems/2723
Seção
I Congresso On-line Nacional de Histologia e Embriologia Humana
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