ASPECTOS IMUNOLÓGICOS DA ALERGIA À PROTEÍNA DO LEITE DE VACA MEDIADA POR IGE

Autores

  • Nicoly Ferreira Silva
  • Adriano Antônio Dos Anjos Lima Filha
  • Ana Carolina Medeiros Andrade
  • Júlia Diniz De Souza
  • Maria Do Socorro Viana Silva De Sá

DOI:

https://doi.org/10.51161/rems/983

Palavras-chave:

Colostro Bovino, Fatores Imunológicos, Hipersensibilidade A Leite

Resumo

Introdução: A alergia à proteína do leite de vaca (APLV) é uma hipersensibilidade alimentar documentada, majoritariamente, como  tipo I (IgE mediada) pela classificação de Gell e Coombs que aborda reações mediadas pelo sistema imune inato e pelo adaptativo. No Brasil, estudos demonstram que crianças com sintomas gastroenterológicos e suspeita de APLV têm prevalência de 5,4% e incidência de 2,2%, sendo essa a alergia alimentar mais comum abaixo de quatro anos de idade. Objetivo: Analisar publicações que abordam os aspectos imunológicos da hipersensibilidade ao leite de vaca mediada por IgE. Material e metodologia: Trata-se de uma revisão bibliográfica, realizada em março de 2021. Para a obtenção dos artigos científicos foi feito um cruzamento de informações advindas das bases de dados Pubmed, Uptodate, LILACS e MEDLINE. Adotou-se os seguintes critérios inclusivos: artigos de revisão sistemática e que foram publicados nos últimos 5 anos (2016-2021). Resultados: As reações alérgicas agudas comumente são respostas imunológicas IgE mediadas - relacionadas a um ou mais alérgenos presentes na composição proteica do leite bovino - sendo mais toleradas a partir dos três anos de idade. Entre os alérgenos, têm-se subtipos da caseína (alfa, beta e kappa), que compõe cerca de 80% do material proteico, e do soro do leite destacando os subtipos BLG (beta-lactoglobulina) e ALA (alfa-lactalbumina). Essas reações variam de sintomas leves a anafilaxia e acontecem até duas horas após exposição ao alérgeno a partir do lançamento de mediadores inflamatórios nos tecidos celulares - sendo a pele o local mais comumente acometido, além de recorrentes manifestações gastrointestinais. Conclusão: Uma vez que não há um único teste ou uma exata combinação de exames capazes de diagnosticar o quadro de APLV, apesar do destaque atribuído ao Teste de Provocação Oral (TPO), é necessária uma avaliação individualizada do paciente com sintomas para essa condição clínica. Deve-se realizar um planejamento nutricional que substitua os lacticínios e apenas reinseri-los na dieta em um momento oportuno, levando em consideração que essa condição tende a ser mais tolerada na idade escolar. Além disso, é essencial a orientação para o uso de epinefrina auto injetável, de modo a evitar reações anafiláticas graves.

Publicado

2021-04-24

Como Citar

Silva, N. F., Filha , A. A. D. A. L., Andrade , A. C. M., De Souza, J. D. ., & De Sá, M. D. S. V. S. (2021). ASPECTOS IMUNOLÓGICOS DA ALERGIA À PROTEÍNA DO LEITE DE VACA MEDIADA POR IGE. Revista Multidisciplinar Em Saúde, 2(2), 41. https://doi.org/10.51161/rems/983

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Imunologia On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
                                                               DAO.retrieveCached(SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2], 3600) % line   91, file: ArticleSearchDAO.inc.php
                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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