AS REPERCUSSÕES IMUNOLÓGICAS CAUSADAS PELA INFECÇÃO POR CORONAVÍRUS AO PORTADOR DE DIABETES MELLITUS

Neslayne Louise Campiol; Gabriel Bessa Tibery Tonelli; Manoel Henrique Carvalho; Larissa Santana Barros; Willian Caetano Rodrigues

doi:10.51161/rems/974

AS REPERCUSSÕES IMUNOLÓGICAS CAUSADAS PELA INFECÇÃO POR CORONAVÍRUS AO PORTADOR DE DIABETES MELLITUS

Autores

Neslayne Louise Campiol
Gabriel Bessa Tibery Tonelli
Manoel Henrique Carvalho
Larissa Santana Barros
Willian Caetano Rodrigues

DOI:

https://doi.org/10.51161/rems/974

Palavras-chave:

Diabetes Mellitus, Imunologia, Infecções Por Coronavírus

Resumo

Introdução: A infecção pelo novo coronavírus (COVID-19) se disseminou rapidamente para diversos países causando milhares de mortes desde dezembro de 2019, quando foi descoberta. A magnitude do COVID-19 é influenciada por comorbidades como a Diabetes Mellitus (DM), que tem sido considerada um fator de risco. Assim, os portadores de DM infectados pelo COVID-19 tem o seu sistema imunológico alterado, agravando o quadro clínico e corroborando para o aumento do número de hospitalizações e da morbimortalidade. Objetivos: Objetivou-se discutir as repercussões que a infecção por COVID-19 pode ocasionar no sistema imunológico do indivíduo portador de Diabetes Mellitus. Material e métodos: Realizou-se uma revisão de literatura a partir de publicações indexadas nas plataformas Pubmed, Medline e Lilacs, utilizando os descritores: Diabetes Mellitus, COVID-19 e imunologia. Incluíram-se artigos disponíveis em português, publicados no período 2020 a 2021. Foram encontrados 83 artigos e selecionados 10, excluíram-se os trabalhos duplicados (26), não disponíveis na íntegra (3) e os que não atendiam ao objeto do estudo (44). Resultados: A DM quando aliada ao coronavírus compõe-se como um fator de risco extremamente aumentado, principalmente quando descompensada. A associação das duas afecções gera problemáticas em diversos sistemas, incluindo o imunológico, cursando com linfopenia, neutrofilia e hiper produção de interleucina-6, proteína C reativa e dímero D (índice de coagulação), ou seja, comprova-se que tais pessoas tendem a apresentar deficiências imunológicas, aumento da inflamação e distúrbios coagulativos em relação aos pacientes com COVID-19 não diabéticos. Outrossim, a DM e alguns dos medicamentos usados no tratamento induzem uma produção elevada de ECA 2 (enzima conversora de angiotensina 2) e de seus receptores (RECA), porta de entrada para SARS-COV-2 por meio da glicoproteína Spike. De forma sucinta, a DM facilita a infecção por COVID-19, agrava a inflamação já desencadeada, prejudica o sistema imunológico e torna-se amplificada pelo coronavírus ao desregular o metabolismo de glicose por alterações diretas na ilhota pancreática. Conclusão: conclui-se que a DM é umas das comorbidades que mais contribui para a morbimortalidade e desenvolvimento de comprometimentos severos na COVID-19, além disso causa deficiência imunológica expressiva e torna o doente suscetível a outras infecções.

Publicado

2021-04-24

Como Citar

Campiol, N. L., Tonelli, G. B. T., Carvalho , M. H., Barros, L. S., & Rodrigues , W. C. (2021). AS REPERCUSSÕES IMUNOLÓGICAS CAUSADAS PELA INFECÇÃO POR CORONAVÍRUS AO PORTADOR DE DIABETES MELLITUS. Revista Multidisciplinar Em Saúde, 2(2), 33. https://doi.org/10.51161/rems/974

Baixar Citação

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Imunologia On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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