EMPREGO DE BIOMARCADORES METABÓLICOS SALIVARES PARA O RASTREAMENTO DO CÂNCER BUCAL

Anildo Alves Brito Júnior; Jeisielle Alves da Anunciação Barreto; Marcelo Victor Coelho Marques; Myllena Miranda Silva; Gabrielle Alves da Anunciação Barreto; Márcia Otto Barrientos; Ivair Tavares Júnior

doi:10.51161/rems/656

EMPREGO DE BIOMARCADORES METABÓLICOS SALIVARES PARA O RASTREAMENTO DO CÂNCER BUCAL

Autores

Anildo Alves Brito Júnior Faculdade Adventista da Bahia
Jeisielle Alves da Anunciação Barreto Fundação Oswaldo Cruz - Bahia
Marcelo Victor Coelho Marques Faculdade Adventista da Bahia
Myllena Miranda Silva Faculdade Adventista da Bahia
Gabrielle Alves da Anunciação Barreto Faculdade Adventista da Bahia
Márcia Otto Barrientos Faculdade Adventista da Bahia
Ivair Tavares Júnior Faculdade Adventista da Bahia

DOI:

https://doi.org/10.51161/rems/656

Palavras-chave:

Câncer bucal, Marcadores biológicos, Saliva

Resumo

Introdução: O câncer bucal é o sexto tipo de câncer mais frequente, sendo sua alta taxa de mortalidade intrinsecamente relacionada ao diagnóstico tardio. A saliva como um fluido oral multiconstituinte, compreende secreções amplamente fornecidas pelo sangue, com potencial para detecção de biomarcadores específicos relacionados ao câncer bucal. Logo, o presente trabalho busca discutir o emprego de biomarcadores metabólicos salivares para o rastreamento e diagnóstico precoce do câncer bucal. Métodos: Trata-se de uma revisão integrativa da literatura, desenvolvida por meio da análise retrospectiva de estudos primários que avaliaram o papel de biomarcadores salivares para o rastreamento do câncer bucal. A base de dados PubMed foi consultada, utilizando os descritores: “biomarkers” AND “saliva” AND “oral cancer”. Foram selecionados 17 estudos publicados nos últimos 5 anos, sem restrições de idioma. Resultados: O contato direto da saliva com lesões de câncer oral a torna uma ferramenta de rastreamento mais específica e potencialmente sensível, sendo registrada na literatura uma gama de biomarcadores salivares (DNA, RNA, mRNA, marcadores de proteína), incluindo citocinas (IL-8, IL-1b, TNF -α), defensina-1, P53, Cyfra 21-1, antígeno específico de polipeptídeo de tecido, fosfatase de especificidade dupla, espermidina / espermina N1 acetil-transferase, profilina-1, cofilina-1 e transferrina. Esses metabólitos salivares combinados são considerados assinaturas moleculares e potenciais indicadores do processo patológico, podendo ser a base de um método clinicamente viável de rastreamento não invasivo do câncer oral. Conclusões: A abordagem combinada de biomarcadores salivares pode ser usada como ferramenta de triagem para melhorar a detecção precoce e a precisão do diagnóstico de câncer bucal.

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Publicado

2021-02-01 — Atualizado em 2021-08-10

Versões

2021-08-10 (2)
2021-02-01 (1)

Como Citar

Brito Júnior, A. A., Barreto, J. A. da A., Marques, . M. V. C., Silva, M. M., Barreto, G. A. da A., Barrientos, M. O., & Tavares Júnior, I. (2021). EMPREGO DE BIOMARCADORES METABÓLICOS SALIVARES PARA O RASTREAMENTO DO CÂNCER BUCAL. Revista Multidisciplinar Em Saúde, 2(3), 1–8. https://doi.org/10.51161/rems/656 (Original work published 1º de fevereiro de 2021)

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Edição

v. 2 n. 3 (2021)

Seção

Artigos de Revisão

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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