INVESTIGAÇÃO DA ATIVIDADE TUBERCULOSTÁTICA DE COMPLEXOS DE PALÁDIO(II)

Autores

  • Valéria da Silva Cavania
  • Alessandra Stevanato
  • Adriana Pereira Duarte
  • Fernando Rogério Pavan
  • Cristiana da e Silva

Palavras-chave:

Complexos de paládio(II), tuberculose, novos fármacos

Resumo

Introdução: A tuberculose representa um sério problema de saúde pública não resolvido, sendo anualmente registrados de um a dois milhões de mortes. Atualmente o tratamento da tuberculose agrega a associação de medicamentos, são os chamados coquetéis. Entretanto, os graves problemas na utilização desses medicamentos relacionam-se ao longo tempo de tratamento (seis a dozes meses), seus efeitos colaterais e as cepas resistentes da M. tuberculosis. Assim, a introdução de íons metálicos para o desenvolvimento de novos medicamentos, oferece uma área de pesquisa potencialmente atraente e rica. Objetivo: Este trabalho teve como objetivo descrever a síntese, a caracterização dos complexos de paládio(II): [PdCl2(isc)PPh3)] (1) e [PdCl2(isn)PPh3)] (2), nos quais isc = isonicotinamida, isn = isoniazida e PPh3 = trifenilfosfina; e a avaliação do potencial tuberculostático dos mesmos. Material e métodos: Os complexos sintetizados foram obtidos pela reação entre o precursor [PdCl2(CH3CN)2] em CH3OH, com a adição dos ligantes isonicotinamida (isc) ou isoniazida (isn), seguido da adição da trifenilfosfina (PPh3), na razão de 1:1. Os complexos foram caracterizados por análise elementar, espectroscopia na região do infravermelho (IV), ressonância magnética nuclear (RMN), análise térmica (TGA-DSC) e a condutividade molar. Os complexos obtidos e seus ligantes foram submetidos aos ensaios de inibição da M. tuberculosis, pela técnica do Microplate Alamar Blue Assay (MABA). Resultados: Os dados de análise elementar, RMN, TGA-DSC e condutividade molar concordaram com as estequiometrias propostas para os dois complexos. Os complexos e seus respectivos ligantes foram submetidos aos ensaios de inibição da M. tuberculosis H37Rv ATCC–27194. Os valores de concentração inibitória mínima (CIM) de 1 e 2 foram de 15,67 ± 5,05 μg/mL e 2,78 ± 0,02 μg/mL, respectivamente. Conclusão: Revela-se que esses complexos de Pd (II) foram mais eficazes que o medicamento padrão, a pirazinamida, que apresenta CIM na faixa de 50,0-100,0 μg/mL).

Publicado

2020-09-01

Como Citar

Cavania, V. da S., Stevanato, A., Duarte, A. P., Pavan, F. R., & e Silva, C. da. (2020). INVESTIGAÇÃO DA ATIVIDADE TUBERCULOSTÁTICA DE COMPLEXOS DE PALÁDIO(II). Revista Multidisciplinar Em Saúde, 1(3), 32. Recuperado de https://editoraime.com.br/revistas/rems/article/view/376
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