INFLUÊNCIA DA OBESIDADE NA SEPSE - UMA REVISÃO DE LITERATURA

Teonis Rocha Felipe da  Silva; Aline César de Lacerda  Sá; Bartira Maraína de Souza  Dantas; Natália Fernandes de Sousa  Silva; Gregorio Fernandes  Gonçalves

doi:10.51161/rems/2941

INFLUÊNCIA DA OBESIDADE NA SEPSE - UMA REVISÃO DE LITERATURA

Autores

Teonis Rocha Felipe da Silva
Aline César de Lacerda Sá
Bartira Maraína de Souza Dantas
Natália Fernandes de Sousa Silva
Gregorio Fernandes Gonçalves

DOI:

https://doi.org/10.51161/rems/2941

Palavras-chave:

SEPSE, OBESIDADE, ADIPOCINAS, RESPOSTA INFLAMATÓRIA

Resumo

Introdução: A sepse é uma resposta inflamatória sistêmica em razão de uma infecção, cuja origem advém de qualquer agente etiológico, sendo as bactérias o principal patógeno. Para a progressão da patologia, a resposta imune e a virulência do agente são decisivas, bem como algumas condições clínicas podem aumentar a suscetibilidade às infecções. A obesidade é uma doença crônica de caráter multifatorial, que tem sido alvo de preocupação mundial. Existem múltiplos fatores que contribuem para o desencadeamento dessa doença, que no geral, é o acúmulo de gordura causada por um consumo de energia na alimentação superior a energia usada pelo organismo para sua manutenção e realização das atividades do dia-a-dia. Objetivo: Apontar os fatores que relacionam a obesidade como um agravante ou gatilho para casos de sepse. Material e métodos: Trata-se de revisão bibliográfica, onde foram consultados sites como PubMed, Periódico Capes e Scielo, através dos descritores: Sepse, Obesidade e Inflamação. Resultado: A resposta inflamatória na obesidade, com origem nos tecidos adiposos, caracteriza-se pela inflamação crônica de baixa intensidade com maior expressão de adipocinas pró-inflamatórias, como interleucina-6, fator de necrose tumoral-alfa, adipisina, angiotensinogênio, leptina, como também fatores de crescimento. Essa resposta inflamatória desencadeia ou agrava, em especial diabetes mellitus tipo 2 e doenças cardiovasculares. As adipocinas, mediadores produzidos pelo tecido adiposo endócrino são responsáveis pela produção de citocinas do tipo Th1 com a Leptina, passando pela função anti-inflamatória da adiponectina e também pela resistina, com sua indução à resistência à insulina. Conclusão: Assim, o cenário inflamatório ocasionado pela obesidade é gênese de vários fatores de risco, dentre eles a sepse, pelo fato de que os pacientes se banham em um estado de estresse hiperglicêmico, tendo também alterações nas adipocinas, elevando os níveis de mediadores pró inflamatórios e de resistinas no soro.

Publicado

2021-12-21

Como Citar

Silva, T. R. F. da ., Sá, A. C. de L. ., Dantas, B. M. de S. ., Silva, N. F. de S. ., & Gonçalves, G. F. . (2021). INFLUÊNCIA DA OBESIDADE NA SEPSE - UMA REVISÃO DE LITERATURA. Revista Multidisciplinar Em Saúde, 2(4), 176. https://doi.org/10.51161/rems/2941

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

I Congresso Brasileiro de Saúde Pública On-line: Uma abordagem Multiprofissional

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
                                                               DAO.retrieveCached(SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2], 3600) % line   91, file: ArticleSearchDAO.inc.php
                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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