A MATURAÇÃO OOCITÁRIA IN VITRO PARA PREVENIR A SÍNDROME  DA HIPERESTIMULAÇÃO OVARIANA

Giovanna Luisa Brandao  Mainieri; Priscila  Murador

doi:10.51161/rems/2727

A MATURAÇÃO OOCITÁRIA IN VITRO PARA PREVENIR A SÍNDROME DA HIPERESTIMULAÇÃO OVARIANA

Autores

Giovanna Luisa Brandao Mainieri
Priscila Murador

DOI:

https://doi.org/10.51161/rems/2727

Palavras-chave:

MATURAÇÃO OOCITÁRIA IN VITRO, SÍNDROME DA HIPERESTIMULAÇÃO OVARIANA, TÉCNICAS REPRODUTIVAS

Resumo

Introdução: Anos atrás, padronizou-se utilizar protocolos de hiperestimulação medicamentosa controlada para captar oócitos, porém a estimulação ovariana não é isenta de riscos. A síndrome da hiperestimulação ovariana (SHO) é a resposta exagerada dos ovários às gonadotrofinas. Divide-se em quatro graus: leve, moderada, grave e crítica. Devido grande quantidade folicular o líquido acumulado nos ovários aumenta a permeabilidade capilar, resultando no efluxo de líquido intravascular para o espaço intersticial. Consequências são alterações hemodinâmicas, de hemoconcentração, líquido nos pulmões, insuficiência renal, trombose e morte. No Brasil é estimado três óbitos a cada 100 mil tratamentos. A maturação in vitro (MIV) apresenta uma alternativa aos tratamentos que utilizam gonadotrofinas, por ser o cultivo in vitro de oócitos imaturos. Objetivo: Esse trabalho busca reunir informações para responder se a MIV tem se mostrado boa alternativa aos tratamentos de reprodução humana assistida objetivando-se prevenir a SHO. Materiais e Métodos: Realizou-se revisão bibliográfica em revistas acadêmicas, comparando dados. Resultados: Respostas das células de mamíferas à MIV: Certo estudo realizado em 1975 utilizando progesterona no meio de cultivo obteve resultado negativo em sua pesquisa, assim como uma pesquisa em 1998 ao utilizar FSH/LH. Utilizando fluido folicular, em 1991, o resultado obtido foi satisfatório. Ao utilizar estrogênio + soro bovino em 1994 o resultado concluiu-se indiferente. Em 1998 e 2000, foi observado resultado positivo ao usar FSH/LH nos estudos. Trazendo nova perspectiva, em 1998 foi proposto o uso de insulina do fluido folicular in vivo + fator de crescimento insulina símile – I + IGF-I obtendo resultados positivos. Em 2017 inúmeros pesquisadores apoiaram o uso de TCM 199 + SSS + FSH + hCG recombinante + estradiol + insulina + FGF alegando ser o maior avanço até a atualidade. Conclusão: O desenvolvimento oocitário adequado demanda sincronia entre a maturação nuclear e citoplasmática. A partir do pensamento contemporâneo de não repetir expressamente o que ocorre in vivo, alguns grupos de pesquisadores sugerem a adição de agentes farmacológicos ao meio de cultivo para evitar a maturação nuclear precoce. A MIV tem demonstrado ser uma alternativa viável para casos com probabilidade de desenvolver complicações da SHO. É inegável a necessidade de mais estudos na área.

Publicado

2021-12-13

Como Citar

Mainieri, G. L. B. ., & Murador, P. . (2021). A MATURAÇÃO OOCITÁRIA IN VITRO PARA PREVENIR A SÍNDROME DA HIPERESTIMULAÇÃO OVARIANA. Revista Multidisciplinar Em Saúde, 2(4), 18. https://doi.org/10.51161/rems/2727

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

I Congresso On-line Nacional de Histologia e Embriologia Humana

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
                                                               DAO.retrieveCached(SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2], 3600) % line   91, file: ArticleSearchDAO.inc.php
                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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