MEIO CONDICIONADO DAS CÉLULAS ESTROMAIS MESENQUIMAIS NA REDUÇÃO DO ESTRESSE OXIDATIVO EM DOENÇAS NEURODEGENERATIVAS

Êndel Alves Gomes de  Oliveira; Andrea Gonçalves  Trentin

doi:10.51161/rems/2715

MEIO CONDICIONADO DAS CÉLULAS ESTROMAIS MESENQUIMAIS NA REDUÇÃO DO ESTRESSE OXIDATIVO EM DOENÇAS NEURODEGENERATIVAS

Autores

Êndel Alves Gomes de Oliveira
Andrea Gonçalves Trentin

DOI:

https://doi.org/10.51161/rems/2715

Palavras-chave:

DOENÇAS NEURODEGENERATIVAS, CÉLULAS-TRONCO, MEIO CONDICIONADO, ESTRESSE OXIDATIVO, TERAPIA CELULAR

Resumo

Introdução: A fisiopatologia dessas doenças envolve uma cascata de eventos celulares e moleculares. O estresse oxidativo (EO) é um dos principais fatores envolvidos nos danos do sistema nervoso central induzindo o surgimento de várias doenças neurodegenerativas (DNs). Novas alternativas de medicina regenerativa para tratamento de doenças crônicas e neurodegenerativas surgem com a aplicabilidade das células-tronco/estromais mesenquimais (CEM). Parte do efeito terapêutico baseia-se na sua sinalização e modulação parácrina pela liberação de fatores tróficos e/ou neuroprotetores. Desse modo, o seu secretoma, obtido em cultura na forma de meio condicionado (MC) é uma alternativa para o tratamento de diversas patologias e na função de inibir e/ou reduzir os danos causados pela ação deletéria do EO pela ativação de via de sinalização de sobrevivência celular. Objetivos: Avaliar o efeito protetor e papel terapêutico do MC-CEM contra o estresse oxidativo envolvido na fisiopatologia nas doenças neurodegenerativas. Material e métodos: Realização de revisão sistemática da literatura, análise de dados e avalição dos efeitos do MC-CEM como papel terapêutico. Resultados: Diversos trabalhos demonstraram efeitos positivos do MC-CEM em modelos de DNs in vivo e in vitro controlando a morte neuronal promovendo neurogênese, sobrevivência, proliferação, plasticidade sináptica, proteção das células nervosas contra a citotoxicidade envolvido no EO. Os efeitos neuroprotetores do MC-CEM podem estar relacionados com o sistema de defesa antioxidante devido à presença de diversos fatores e biomoléculas do seu secretoma. Conclusão: Tem-se percebido através da literatura que o uso do MC-CEM apresenta uma contribuição terapêutica para retardar e/ou melhorar a neurodegeneração na aplicação em citoterapias específicas e demais terapias celulares vigentes.

Publicado

2021-12-13

Como Citar

Oliveira, Êndel A. G. de ., & Trentin, A. G. . (2021). MEIO CONDICIONADO DAS CÉLULAS ESTROMAIS MESENQUIMAIS NA REDUÇÃO DO ESTRESSE OXIDATIVO EM DOENÇAS NEURODEGENERATIVAS. Revista Multidisciplinar Em Saúde, 2(4), 7. https://doi.org/10.51161/rems/2715

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

I Congresso On-line Nacional de Histologia e Embriologia Humana

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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