Introdução: A doença do coronavírus (COVID-19) tem como característica marcante o comprometimento respiratório, levando vários pacientes a quadros graves. Ademais, os impactos no sistema circulatório conduziram a uma tentativa de compreensão dos achados vasculares nos pacientes, caracterizado pela mudança nos níveis do dímero D. Estudos sugeriram que os níveis elevados de D-dímero, um produto de degradação da fibrina e importante marcador dos níveis de coagulação no corpo, estão associados a um aumento na mortalidade por COVID-19. Objetivos: Esse estudo objetivou a realização de uma revisão dos principais trabalhos dessa área para profunda análise sobre a alteração na concentração de dímero D em pacientes infectados pelo SARS-CoV-2. Material e Métodos: Trata-se de uma revisão sistemática de ensaios clínicos, ensaios clínicos randomizados, estudos observacionais e estudos clínicos realizados em humanos no último ano, tendo como base de dados o PubMed. Para a seleção dos trabalhos, os operadores booleanos utilizados foram: (COVID-19) AND (D-dimer). Desse modo, foram encontrados 141 artigos no total, dos quais 11 se encaixavam no estudo. Resultados: Nos achados, comprovou-se a correlação clínica da elevação desse biomarcador em pacientes graves de COVID-19, ao mesmo tempo em que o tratamento com anticoagulantes como fator de proteção nessa doença também foi analisado, sendo associado à diminuição da mortalidade em pacientes graves. Conclusão: Observou-se uma correlação entre elevados níveis do Dímero D e agravantes de quadros clínicos da COVID-19 relacionados aos distúrbios causados que geraram diversas disfunções em órgãos de pacientes de COVID-19 críticos. Evidenciou-se importância do foco de estudos em torno da tentativa de correlacionar biomarcadores com a evolução do quadro, além de elucidar as dúvidas ainda persistentes nesse tema.
Publicado
2021-10-07
Como Citar
Paula, G. S. de ., Barros, I. R. ., Ataides, J. V. B. D. Q. E. ., Gomes, M. U. ., & Almeida, T. A. C. D. . (2021). O DÍMERO D E A COVID-19: UMA REVISÃO SISTEMÁTICA. Revista Multidisciplinar Em Saúde, 2(4), 23. https://doi.org/10.51161/rems/2164
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