Início
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Arquivos
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v. 2 n. 4 (2021)
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I Congresso Brasileiro de Doenças Infectocontagiosas On-line
O DÍMERO D E A COVID-19: UMA REVISÃO SISTEMÁTICA
Autores
Gabriella Salomão de Paula
Izabel Ribeiro Barros
João Victor Benevenuto De Queiroz E Ataides
Manuela Uchôa Gomes
Thiago Augusto Calixto De Almeida
Palavras-chave:
COVID-19, DÍMERO D, TROMBOEMBOLISMO
Resumo
Introdução: A doença do coronavírus (COVID-19) tem como característica marcante o comprometimento respiratório, levando vários pacientes a quadros graves. Ademais, os impactos no sistema circulatório conduziram a uma tentativa de compreensão dos achados vasculares nos pacientes, caracterizado pela mudança nos níveis do dímero D. Estudos sugeriram que os níveis elevados de D-dímero, um produto de degradação da fibrina e importante marcador dos níveis de coagulação no corpo, estão associados a um aumento na mortalidade por COVID-19. Objetivos: Esse estudo objetivou a realização de uma revisão dos principais trabalhos dessa área para profunda análise sobre a alteração na concentração de dímero D em pacientes infectados pelo SARS-CoV-2. Material e Métodos: Trata-se de uma revisão sistemática de ensaios clínicos, ensaios clínicos randomizados, estudos observacionais e estudos clínicos realizados em humanos no último ano, tendo como base de dados o PubMed. Para a seleção dos trabalhos, os operadores booleanos utilizados foram: (COVID-19) AND (D-dimer). Desse modo, foram encontrados 141 artigos no total, dos quais 11 se encaixavam no estudo. Resultados: Nos achados, comprovou-se a correlação clínica da elevação desse biomarcador em pacientes graves de COVID-19, ao mesmo tempo em que o tratamento com anticoagulantes como fator de proteção nessa doença também foi analisado, sendo associado à diminuição da mortalidade em pacientes graves. Conclusão: Observou-se uma correlação entre elevados níveis do Dímero D e agravantes de quadros clínicos da COVID-19 relacionados aos distúrbios causados que geraram diversas disfunções em órgãos de pacientes de COVID-19 críticos. Evidenciou-se importância do foco de estudos em torno da tentativa de correlacionar biomarcadores com a evolução do quadro, além de elucidar as dúvidas ainda persistentes nesse tema.
Como Citar
Paula, G. S. de ., Barros, I. R. ., Ataides, J. V. B. D. Q. E. ., Gomes, M. U. ., & Almeida, T. A. C. D. . (2021). O DÍMERO D E A COVID-19: UMA REVISÃO SISTEMÁTICA. Revista Multidisciplinar Em Saúde , 2 (4), 23. https://doi.org/10.51161/rems/2164
Seção
I Congresso Brasileiro de Doenças Infectocontagiosas On-line
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