O POTENCIAL TERAPÊUTICO DOS IMUNOMODULADORES NA COVID-19

Agna Lene de Araújo  Ribas; Douglas Felipe De Brito  Alves; Felipe Toledo  Lucas; Alcione Oliveira Dos  Santos; Luan Felipo Botelho  Souza

doi:10.51161/rems/2159

O POTENCIAL TERAPÊUTICO DOS IMUNOMODULADORES NA COVID-19

Autores

Agna Lene de Araújo Ribas
Douglas Felipe De Brito Alves
Felipe Toledo Lucas
Alcione Oliveira Dos Santos
Luan Felipo Botelho Souza

DOI:

https://doi.org/10.51161/rems/2159

Palavras-chave:

COVID-19, IMUNOMODULADORES, SARS-COV-2

Resumo

Introdução: A pandemia global causada pelo novo coronavírus (COVID-19) cursa com infecção predominantemente no sistema respiratório. O quadro clinico é classificado em leve, moderado e grave a depender do grau de virulência e/ou da resposta hiper inflamatória do hospedeiro. Sendo de caráter grave quando há aumento exacerbado dos níveis de citocinas pró-inflamatórias (IL-1, IL-6 e TNF), que por conseguinte pode resultar na Síndrome da Angústia Respiratória Aguda (SARS), Síndrome do Desconforto Respiratório Agudo (SDRA) e uma resposta inflamatória sistêmica. Portanto, o emprego dos fármacos imunomoduladores em pacientes graves tem como intuito atenuar a resposta inflamatória em prol de um melhor prognóstico para esses pacientes. Objetivo: Avaliar as evidências disponíveis sobre o efeito do tratamento da terapia imunomoduladora na COVID-19. Material e Métodos: Trata-se de uma revisão sistemática sobre os fármacos Anakinra, Inibidor de fator de necrose tumoral, Tocilizumab, Siltuximab, Sarilumab, Tofacitinib e Baracitinibe. A coleta dos dados foi realizada pelas plataformas eletrônicas Scielo, NCBI, PubMed e Clinicaltrials.gov onde foram incluídos artigos científicos publicados entre os anos de 2020 a 2021, nos idiomas português, espanhol e inglês. Sendo selecionados os estudos sobre coorte prospectivo e retrospectivo, ensaio clinico, ensaio clínico randomizado. A análise dos dados fora tabulada por meio do software Microsoft Excel® 2010 para análise descritiva. Resultados: Foram incluídos 42 estudos. Onde verificou-se redução do parâmetro inflamatório com uso de Anakinra e Siltuximabe. E diminuição da necessidade de ventilação mecânica com o emprego de Anakinra, Tocilizumabe e Siltuximabe. O aumento da sobrevida fora evidenciado com a administração de Anakinra, Siltuximabe, Tofacitinib e Baracitinib. Salienta-se que Tocilizumabe e Tofacitinib obtiveram resultados contraditórios nesse parâmetro. O tempo de internação atenuou-se com a aplicação de Anakinra e Tocilizumabe. O Inibidor De Fator De Necrose Tumoral não apresentou benefício com relação ao tempo hospitalização ou mortalidade. Conclusão: Há indícios de que o uso de imunomoduladores na COVID-19 grave podem melhorar o prognóstico dos pacientes. Entretanto, esses resultados devem ser confirmados uma vez que há estudos contraditórios e com pouca amostragem. Tal fato deve ser realizado por meio de ensaios clínicos controlados antes sua implementação como cuidado padrão na COVID-19.

Publicado

2021-10-07

Como Citar

Ribas, A. L. de A. ., Alves, D. F. D. B. ., Lucas, F. T. ., Santos, A. O. D. ., & Souza, L. F. B. . (2021). O POTENCIAL TERAPÊUTICO DOS IMUNOMODULADORES NA COVID-19. Revista Multidisciplinar Em Saúde, 2(4), 18. https://doi.org/10.51161/rems/2159

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

I Congresso Brasileiro de Doenças Infectocontagiosas On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
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                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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