ASPECTOS IMUNOLÓGICOS DE PATOGENICIDADE DA LEISHMANIOSE TEGUMENTAR AMERICANA CUTÂNEA

Autores

  • Diego Bezerra Soares
  • Isabela Reis Manzoli
  • Lohraine Talia Domingues
  • Paulo Schumann Neto
  • Mariana Kely Diniz Gomes De Lima

DOI:

https://doi.org/10.51161/rems/1445

Palavras-chave:

ASPECTO IMUNOLÓGICO, LEISHMANIOSE CUTÂNEA, PATOGENICIDADE

Resumo

Introdução: A leishmaniose tegumentar americana cutânea é um tipo de doença infecciosa não contagiosa causada por um protozoário do gênero Leishmania sp. que acomete principalmente a pele e as mucosas. Ademais, a transmissão é pelo repasto sanguíneo do mosquito flebotomíneo infectado com a forma promastigota presente na saliva do inseto. Além disso, essa patologia caracteriza-se por um acometimento de lesão ulcerada indolor única ou múltipla. Objetivos: Devido a elevada prevalência no número de casos de leishmaniose cutânea na região norte brasileira essa doença pode ser definida como uma endemia, uma vez que foram registrados nessa macrorregião cerca de 30% de todos os casos notificados em 2017. Nesse contexto, é primordial mais estudos que esclareçam a padronização dessa enfermidade. Dessa forma, foi levantada a seguinte problemática “Como ocorrem os fatores imunológicos de patogenicidade da leishmaniose? ”.Materiais e Método: A pesquisa consiste em uma revisão de literatura retrospectiva, com o intuito de elucidar o papel imunológico de virulência da infecção por leishmaniose cutânea. Resultados: A partir desse estudo foi possível observar que durante a picada do mosquito já se libera uma substância vasodilatadora chamada Maxidilan presente na saliva do flebotomíneo capaz de inibir as células apresentadoras de Antígenos (APC) e a citocina IL-12 que são responsáveis por desencadear a ativação da resposta imune contra os patógenos, favorecendo assim a infecção. Outrossim, os mecanismo sinalizadores de células, a ligação do parasita e a influência dos co-estimuladores de determinadas citocinas corroboram a disseminação do parasita, uma vez que por meio da inibição das células que apresentam esse antígeno, a leishmania consegue através da sua forma ativa começar um mecanismo de tropismo migrando para as regiões de sua preferência infectante onde induz a estimulação de macrófagos fixos se ligando a eles por estimuladores e inibindo o processo de fagocitose. Conclusão: Por meio desse estudo observou-se um importante aspecto de patogenicidade associado aos aspectos imunológicos presentes durante a infecção que oferece vantagem ao parasita sobre o sistema imune do hospedeiro. 

Publicado

2021-07-28

Como Citar

Soares , D. B. ., Manzoli, I. R. ., Domingues, L. T. ., Neto, P. S., & Lima, M. K. D. G. D. (2021). ASPECTOS IMUNOLÓGICOS DE PATOGENICIDADE DA LEISHMANIOSE TEGUMENTAR AMERICANA CUTÂNEA. Revista Multidisciplinar Em Saúde, 2(3), 43. https://doi.org/10.51161/rems/1445

Edição

v. 2 n. 3 (2021)

Seção

II Congresso Brasileiro de Saúde On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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