EFEITOS ADVERSOS NO TRATAMENTO POR IMUNIZAÇÃO MEDIADA POR ANTICORPOS - REVISÃO DE LITERATURA

Autores

  • Maria Sílvia Prestes Pedrosa
  • Paula Taquita Serra
  • Wenberger Lanza Daniel De Figueiredo
  • Matheus Vinícius De Souza Carneiro

DOI:

https://doi.org/10.51161/rems/1003

Palavras-chave:

Covid-19, Imunoterapia, Reações Adversas

Resumo

Introdução: Desde do início da pandemia de COVID-19, foi exigido um rápido avanço da indústria farmacêutica, com a finalidade de achar tratamentos eficazes para o novo coronavírus e quais seriam os possíveis efeitos adversos ligados a estes fármacos. Dentro destes efeitos adversos, deve ser avaliado os riscos e os benefícios voltados à imunoterapia com anticorpos. Objetivos: ​Relatar as reações adversas do tratamento para COVID-19 por imunoterapia com anticorpos monoclonais e policlonais. ​ Material e métodos: Realizamos uma revisão de literatura na plataforma de pesquisa ​PubMed combinando os descritores ​Monoclonal Antibodies, Immunotoxins, “Antibodies, Bispecific”e​CoronavirusInfectionsd​eestudosclínicosrandomizadosgratuitos completos publicados há 1 ano. Excluindo os textos não relacionados ao tema ou contendo dados secundários. ​ Resultados: Obteve-se 9 artigos, nos quais foram descritos efeitos adversos destas medicações, e entre eles, consequências graves, como morte. Teve também em um artigo que relata não ter efeito adverso relacionado ao plasma e um outro artigo que não relatou efeitos adversos. Dessa forma, observamos que no LY-CoV555 os efeitos mais comuns foram náusea; no grupo REGN-CO2 foram reações de hipersensibilidade de grau 2; no grupo do Tocilizumabe os efeitos adversos relatados foram morte, hipersensibilidade a infusão, infecções, trombose, embolia pulmonar, acidente vascular cerebral, além de terem descrito que em pacientes graves aumentou a mortalidade comparado ao tratamento padrão; no grupo Tocilizumabe com Favipiravir, foi relatado efeitos comuns como aumento da transaminase, diarreia e hiperuricemia, não teve nenhuma reação adversa grave e as demais reações aliviaram com o tempo.

Publicado

2021-04-24

Como Citar

Pedrosa, M. S. P., Serra, P. T., De Figueiredo , W. L. D. ., & Carneiro , M. V. D. S. (2021). EFEITOS ADVERSOS NO TRATAMENTO POR IMUNIZAÇÃO MEDIADA POR ANTICORPOS - REVISÃO DE LITERATURA. Revista Multidisciplinar Em Saúde, 2(2), 60. https://doi.org/10.51161/rems/1003

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Imunologia On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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