CONTROLADORES DE ELITE E HIV: UMA REVISÃO DE LITERATURA

Autores

  • Francisco Eberson Da Silva Machado
  • Francisco Eberson Da Silva Machado
  • Luiz Carlos Teles Nunes
  • Milena Xavier Silva Barbosa
  • Ana Letícia Moreira Silva
  • Ana Ruth Sampaio Grangeiro

DOI:

https://doi.org/10.51161/rems/998

Palavras-chave:

Aids, Elisa, Western Blot

Resumo

Introdução: A Síndrome da imunodeficiência Adquirida (AIDS) é uma consequência crônica da infecção por o Vírus da Imunodeficiência Humana (HIV) pertencente à familia Retroviridae. É estruturalmente constituído por capsídeo icosaédrico, envelopado por fosfolipidios, onde localizam-se as proteínas virais. A AIDS é consequência do não tratamento do paciente com HIV, ocorrendo a diminuição dos linfócitos TCD4, pois o vírus realiza o processo de adsorção em células apresentadoras de antígeno ocorrendo todo o processo da replicação viral intra celular. Alguns indivíduos, apesar de serem portadores do HIV, não apresentam essa diminuição de linfócitos e são chamados de controladores de elite. Objetivo: Fornecer informações sobre os controladores de elite e uma possível cura do HIV com base em estudos recentes. Materiais e Métodos: Tratou-se de uma revisão de literatura, que buscou evidenciar e discutir sobre o mecanismo imunológico dos  controladores de elite. Utilizou-se publicações científicas, em idioma português, pesquisados no Google Acadêmico e Scielo entre 2005 a 2019, com os descritores: Controladores de elite e HIV. Desenvolvimento: Os controladores de elite apresentam as concentrações de linfócito TCD4 normais, porém associado a alguma outra patologia como, por exemplo, a tuberculose pulmonar pode levar a ocorrer uma queda lenta desses linfócitos ocasionado uma evolução para AIDS, além disso, os controladores de elite apresentam uma proteção natural que permite que o vírus fique indetectável ou com carga viral abaixo de 50 copias de RNA viral/mL, mesmo sem terapia com antirretrovirais. O diagnóstico confirmatório para os controladores de elite baseia-se no Elisa de 3ª geração e Western Blot. Conclusão: Através dessa pesquisa foi possível observar que pacientes controladores de elite vão possuir interferências no diagnóstico do HIV, tornando necessária a utilização de outras metodologias para fechar o diagnóstico.  

Publicado

2021-04-24

Como Citar

Machado , F. E. D. S., Machado , F. E. D. S., Nunes, L. C. T., Barbosa, M. X. S., Silva, A. L. M., & Grangeiro , A. R. S. (2021). CONTROLADORES DE ELITE E HIV: UMA REVISÃO DE LITERATURA. Revista Multidisciplinar Em Saúde, 2(2), 56. https://doi.org/10.51161/rems/998

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Imunologia On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php