Início
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Arquivos
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v. 1 n. 1 (2020): Edição Especial: Anais do I Congresso Brasileiro de Ciências Farmacêuticas On-line
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Anais de Evento
AVALIAÇÃO DA ATIVIDADE ANTI-INFLAMATÓRIA DA Tribulus terrestris EM RAW 264.7 ESTIMULADA COM LPS
Autores
José Vinicius Firmiano Alves
Faculdade Presidente Antônio Carlos
Victor Fernandes Ribeiro
Jair Adriano Kopke Aguiar
Faculdade Presidente Antônio Carlos
Luiz Gustavo Oliveira
Faculdade Presidente Antônio Carlos
Palavras-chave:
RAW 264.7, Tribulus terrestris, Anti-inflamatório
Resumo
Introdução: Tribulus terrestris é uma planta rastejante, do gênero Zygophyllaceae, de origem de regiões temperadas e tropicais da Europa, do sul da Ásia, da África, da Austrália e do Sudão. Foram descritas uma diversidade de atividades farmacológicas desta planta, dentre elas podem ser citadas as propriedades afrodisíacas, anti-inflamatórias, antimicrobianas e potenciais antioxidantes. Existem vias de sinalização nas células RAW 264.7, que ativam uma variedade de fatores de transcrição, incluindo NF-kB. Objetivo: Avaliar os efeitos de Tribulus terrestris no processo inflamatório estimulado por LPS em linhagem de macrófagos RAW 264.7. Material e métodos: Como matéria prima foi utilizado extrato seco de Tribulus terrestris, a viabilidade celular da linhagem RAW 264.7 em contato com a Tribulus terrestris foi avaliada por ensaio de MTT com as concentrações (10; 20; 40; 60; 80; 100; 150; 200; 300; 400 e 500 μg/mL). Foi determinada a concentração de óxido nítrico (NO), pelo método de Griess, a Translocação do NF-kB foi realizado pelo teste de imunofluorescência determinando como o NF-kB se manifesta quando a célula entra em contato com a Tribulus terrestris. Resultados: O teste de viabilidade celular apontou para uma IC50 de 226,1 μg/mL. Observamos que em macrófagos estimulados com LPS e tratados com Tribulus terrestris houve redução na concentração de NO, quando comparados com o controle. Além disso, verificamos uma menor translocação de NF-kB quando a célula é tratada pela Tribulus terrestris. Conclusão: Foi demonstrado que a Tribulus terrestris exerce efeitos anti-inflamatórios por reduzir mediadores pró-inflamatórios, inibindo também a translocação de NF-kB.
Como Citar
Firmiano Alves , J. V., Fernandes Ribeiro, V. ., Kopke Aguiar, J. A. ., & Oliveira, L. G. . (2020). AVALIAÇÃO DA ATIVIDADE ANTI-INFLAMATÓRIA DA Tribulus terrestris EM RAW 264.7 ESTIMULADA COM LPS. Revista Multidisciplinar Em Saúde , 1 (1), 13. Recuperado de https://editoraime.com.br/revistas/rems/article/view/98
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