A UTILIZAÇÃO DE FÁRMACOS QUELANTES DE FERRO COMO DEFESA CONTRA FUNGOS PATOGÊNICOS

Autores

  • Anderson da Cunha Costa Universidade Federal do Ceará
  • Vandbergue dos Santos Pereira
  • Raimunda Sâmia Nogueira Brilhante
  • Marcos Fábio Gadelha Rocha

Palavras-chave:

Íon ferro, Patógenos, Quelantes

Resumo

Introdução: O sequestro de ferro no organismo pelo de uso de fármacos quelantes representa interessante perspectiva de defesa em casos de falha da terapêutica antimicrobiana tradicional, ou nos casos de pacientes com alguma imunodeficiência. Agentes quelantes são utilizados para sequestrar o íon ferro e alguns têm demostrado efeitos inibitórios contra patógenos. Esses quelantes podem remover o excesso do íon metálico por diferentes mecanismos. Objetivo: Revisar a literatura em relação a utilização de quelantes de ferro frente a fungos. Material e métodos: Foi feita uma busca nas bases de dados PubMed e Scielo, no Portal de periódicos Capes e no Portal da Pesquisa BVS nos meses de outubro de 2018 a setembro de 2019. Resultados: 3 artigos foram selecionados e analisados demostrando que Deferoxamina apresenta efeitos antifúngicos, frente Rhizopus spp., sendo observado aumento na taxa de sobrevivência dos animais com quadros de infecção sistêmica. Deferiprona tem a capacidade de ligar-se ao ferro que se encontra armazenado na ferritina ou adentrar às células podendo haver combinação de deferiprona com outros quelantes como deferoxamina. A deferiprona apresenta atividade antifúngica frente a Cryptococcus spp., Saccharomyces cerevisiae e A. fumigatus. O quelante deferasirox é utilizado como antifúngico no tratamento de mucormicose, apresentando também Inibição de Cryptococcus spp., Saccharomyces cerevisiae e Rhizopus spp. O ácido etilenoiaminotetracético (EDTA) teve sua ação antifúngica testada frente a células planctônicas de S. cerevisiae e Cryptococcus spp., e biofilmes de C. neoformans. Conclusão: O uso de fármacos quelantes contra fungos de importância médica parece ser uma estratégia promissora uma vez que a revisão de literatura realizada demonstra resultados interessantes de tal tratamento com quelantes, demonstrando perspectiva para tratamentos futuros.

Publicado

2020-04-01

Como Citar

da Cunha Costa, A., dos Santos Pereira, V. ., Nogueira Brilhante, R. S. ., & Fábio Gadelha Rocha, M. . (2020). A UTILIZAÇÃO DE FÁRMACOS QUELANTES DE FERRO COMO DEFESA CONTRA FUNGOS PATOGÊNICOS. Revista Multidisciplinar Em Saúde, 1(1), 4. Recuperado de https://editoraime.com.br/revistas/rems/article/view/89

Edição

v. 1 n. 1 (2020): Edição Especial: Anais do I Congresso Brasileiro de Ciências Farmacêuticas On-line

Seção

Anais de Evento

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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