T. cruzi, Benzonidazol, Resposta imunológica, Imunoregulação, susceptibilidade/resistência
Resumo
Introdução: Estudos sugerem que o tratamento quimioterápico estimula o sistema imunológico em camundongos infectados com cepas do T. cruzi. Objetivo: avaliar a influência do tratamento com Benzonidazol sobre a resposta imunológica celular em camundongos infectados com a cepa Y (suscetível) e Colombiana (resistente). Material e métodos: 150 camundongos, subdivididos em: Infectados tratados cepa Y (YT) e não tratados (Y-NT); Colombiana tratados (COL-T) e não tratados (COL-NT), Tratados não infectados (TNI) e Controles sem tratamento (CI). O inóculo foi 1,0 x 104 por via intraperitoneal. Os procedimentos estiveram de acordo ao protocolo CEUA, 013/09. O tratamento foi iniciado no pico parasitêmico das cepas, sendo no 7º dia após a infecção nos infectados pela cepa Y e, nos tratados e não infectados, no 18º nos infectados pela cepa Colombiana. A quimioterapia foi em 60 doses (100mg/kg/dia). Os camundongos eutanasiados na fase aguda e crônica nos grupos tiveram a resposta celular investigada pelas citocinas IL-6 IL-10, MCP-1, INF-γ e TNF-α e pelas subpopulações celulares no baço de CD4+ , CD8+ , células de memórias CD62L, células B e macrófagos. Resultados: as citocinas circulantes IL-6 IL-10, MCP-1, INF-γ e TNF-α, foram mais elevadas nos animais infectados com a cepa Y, o tratamento com Benz, não alterou os índices circulantes nos TNI. A citometria na fase aguda demonstrou maior frequência de CD4+ e CD8+ no grupo TNI; de células de memória (CD62L/CD4 e CD8) no grupo YT; de CD11b no grupo COL-NT fase aguda e na YT na fase crônica; e de células B (B220) no grupo CI. Na fase crônica maior frequência de CD4+ e CD8+ no grupo COL-T; de células de memória: (CD4/CD62L) no grupo YT e (CD8/CD62L) no COL-T; de CD11b no YT; e de células B (B220) CI. Conclusão: Nossos resultados sugerem que o tratamento com Benz tem influência na resposta imunológica celular em camundongos.
Publicado
2021-03-01
Como Citar
Lins, . L. C., Pinto, . I. C., Santos, N. L. S. dos, Silva, V. de O., & Guerreiro, M. L. da S. (2021). INFLUÊNCIA DA QUIMIOTERAPIA NA RESPOSTA IMUNOLÓGICA CELULAR EM CAMUNDONGOS INFECTADOS COM AS CEPAS Y E COLOMBIANA DO TRYPANOSOMA CRUZI. Revista Multidisciplinar Em Saúde, 2(1), 66. https://doi.org/10.51161/rems/741
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