Introdução: A artrite reumatoide (AR) é uma doença autoimune de caráter inflamatório e crônico caracterizada por uma sinovite crônica e simétrica, que leva a erosão do osso e cartilagem. Objetivo: Relacionar a resposta inflamatória de AR e a influência das parasitoses intestinais. Metodologia: Revisão bibliográfica de artigos disponibilizados nas plataformas Scielo, Pubmed e Scientific Research Publising, nas línguas portuguesa e inglesa, datados entre 2008 a 2019, com os seguintes descritores: artrite reumatoide parasitoses intestinais, enteroparasitoses pacientes com AR, influência das parasitoses intestinais em pacientes com AR. Resultados: A membrana sinovial é considerada o tecido no qual se inicia e se mantém o processo inflamatório na AR. Atualmente, a causa de AR é a desregulação da produção de interleucina (IL)‐ 17, responsável pela ativação das células T e B, bem como dos macrófagos, que liberam citocinas como IL‐ 1 , IL‐ 6 e fator de necrose tumoral (TNF‐ α). Estudos indicam que helmintos podem modular a resposta imune proporcionando um ambiente anti-inflamatório que ajude sua sobrevivência no hospedeiro, anulando respostas imunes pró-inflamatórias, suprimem respostas dos linfócitos Th-1 e Th-17, além de estimular o desenvolvimento de respostas dos linfócitos Th-2, importantes nas doenças reumáticas autoimunes, como AR, pois a infecção de helmintos contribui para o alívio dos sintomas. Estudos indicam que Schistosoma mansoni, Schistosoma japonicum, Ascaris suum, Heligmosomoides polygyrus bakeri e Hymenolepsis diminuta são parasitas que possuem efeito protetor no processo inflamatório são. Um estudo, o qual fez uso de administração de um extrato de Ascaris suum na artrite experimental induzida por colágeno e por zimosan em ratos e camundongos, assinalou melhoria clínica e estrutural nas duas tipologias, reduzindo a liberação de mediadores inflamatórios como o NO, IL-1 β e IL-10. O efeito benéfico ocorreu a nível funcional e estrutural, abrangendo hiperalgesia articular, redução de danos da cartilagem articular, prevenção da perda de glicosaminoglicanos e revogação da sinovite crônica com redução de macrófagos e linfócitos. Conclusão: A produção de um ambiente imunologicamente controlado como resultado da infecção por helmintos pode diminuir a severidade de uma doença reumática simultânea. Helmintos influenciam beneficamente na resposta inflamatória, podendo auxiliar no tratamento de doenças autoimunes como a AR.
Publicado
2021-03-01
Como Citar
Lazzarotto, . E. L., Gobi, F. R., da Silva, K. G., & D’Agostini, . F. M. (2021). A INFLUÊNCIA DAS PARASITOSES INTESTINAIS SOBRE A SUPRESSÃO DA RESPOSTA PRÓ-INFLAMATÓRIA EM PACIENTES COM ARTRITE REUMATOIDE. Revista Multidisciplinar Em Saúde, 2(1), 23. https://doi.org/10.51161/rems/701
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
Deprecated: Function get_magic_quotes_runtime() is deprecated in /home/editoraime/public_html/revistas/lib/pkp/lib/vendor/adodb/adodb-php/adodb.inc.php on line 2067
Deprecated: Function get_magic_quotes_runtime() is deprecated in /home/editoraime/public_html/revistas/lib/pkp/lib/vendor/adodb/adodb-php/adodb.inc.php on line 2067
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
Deprecated: Function get_magic_quotes_runtime() is deprecated in /home/editoraime/public_html/revistas/lib/pkp/lib/vendor/adodb/adodb-php/adodb.inc.php on line 2067
Notice: Deprecated call to Smarty2 function get_template_vars in /home/editoraime/public_html/revistas/lib/pkp/classes/template/PKPTemplateManager.inc.php on line 1930
Notice: Deprecated call to Smarty2 function get_template_vars in /home/editoraime/public_html/revistas/lib/pkp/classes/template/PKPTemplateManager.inc.php on line 1930
Notice: Deprecated call to Smarty2 function get_template_vars in /home/editoraime/public_html/revistas/lib/pkp/classes/template/PKPTemplateManager.inc.php on line 1930
Este é um conteúdo de acesso aberto distribuído sob os termos da Creative Commons Attribution License.