INFLUÊNCIA DO POLIMORFISMO GENÉTICO DO RECEPTOR II DO TGF BETA NA APRESENTAÇÃO CLÍNICA DE PACIENTES COM LEUCEMIA LINFOIDE AGUDA INFANTOJUVENIL NA POPULAÇÃO BRASILEIRA

Autores

  • Alberto Yoich Sakaguchi
  • Marla Karine Amarante
  • Carlos Eduardo Coral Oliveira
  • Fausto Celso Trigo
  • Maria Angelica Ehara Watanabe

DOI:

https://doi.org/10.51161/rems/625

Palavras-chave:

LLA, polimorfismo genético, prognóstico, suscetibilidade, TGFBR2

Resumo

Introdução: A leucemia linfoide aguda (LLA) é uma neoplasia hematológica que acomete a diferenciação celular e a proliferação exacerbada de células precursoras das linhagens B, T e Natural Killer, apresentando maior incidência na faixa pediátrica. O receptor para o fator de crescimento transformador beta (TGFβR) parece estar envolvido em doenças hematológicas, e um polimorfismo de nucleotídeo único foi identificado em sua região promotora (G-875A) parecendo modificar a expressão de TGFβRII nas células. Objetivo: Avaliar o envolvimento do TGFβRII G-875A na LLA infantil brasileira, com foco na suscetibilidade, parâmetros clínico-patológicos e estratificação de risco. Material e métodos: Estudo de associação caso-controle, envolvendo 127 pacientes com LLA e 161 crianças livres de neoplasia. A avaliação foi realizada através da reação em cadeia da polimerase (PCR) seguida da análise do polimorfismo do comprimento do fragmento de restrição (RFLP). Resultados: Em relação à distribuição dos genótipos, não houve diferença estatisticamente significativa entre os subgrupos de LLA e as crianças controle. Verificou-se que o G-875A foi estatisticamente associado ao aumento da suscetibilidade para LLA-B no modelo recessivo (OR = 2,16; IC = 1,02–4,57; p <0,05), também foi observada associação significativamente aumentada para alto risco (AR) para recidiva no mesmo modelo (OR = 5,14; IC = 1,05–25,12; p <0,05). Além disso, foi observada correlação positiva entre o grupo de risco e o polimorfismo G-875A no modelo recessivo na LLA-B (p = 0,02). Em relação à LLA-T, foi observada correlação positiva entre recidiva e G-875A nos modelos aditivo e dominante (p=0,05 e p=0,028, respectivamente). Conclusão: Verificou-se que o G-875A foi associado ao aumento da suscetibilidade para LLA-B e AR para recidiva em modelo recessivo. Também houve correlação positiva entre a recidiva de LLA e G-875A nos modelos aditivo e dominante, podendo este polimorfismo ser um forte candidato a um possível marcador prognóstico na LLA.

Revista Multidisciplinar em Saúde - V. 2, N. 1, 2021

Publicado

2021-02-01

Como Citar

Sakaguchi, A. Y., Amarante, M. K., Oliveira, C. E. C., Trigo, F. C., & Watanabe, . M. A. E. (2021). INFLUÊNCIA DO POLIMORFISMO GENÉTICO DO RECEPTOR II DO TGF BETA NA APRESENTAÇÃO CLÍNICA DE PACIENTES COM LEUCEMIA LINFOIDE AGUDA INFANTOJUVENIL NA POPULAÇÃO BRASILEIRA. Revista Multidisciplinar Em Saúde, 2(1), 16. https://doi.org/10.51161/rems/625

Edição

v. 2 n. 1 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Hematologia Clínico-laboratorial On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php