Início
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Arquivos
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v. 1 n. 3 (2020): Edição Especial: Anais do I Congresso Brasileiro de Saúde On-line
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Anais de Evento
PERFIL CITOGENÉTICO E MOLECULAR DA LEUCEMIA LINFOBLÁSTICA AGUDA EM CÉLULAS T, DE PACIENTES PEDIÁTRICOS
Autores
Emanuela Bezerra Gueiros
Maria do Socorro Pombo Oliveira
Terezinha de Jesus Marques Salles
Elda Pereira Noronha
Palavras-chave:
citogenética, biologia molecular, leucemia
Resumo
Introdução: A LLA-T é uma neoplasia maligna hematológica agressiva e representa 15% das LLAs da infância. Atualmente, são descritas anormalidades genéticas específicas com importância no diagnóstico e prognóstico da doença, sendo assim é de suma importância os estudos citogenéticos e moleculares para a compreensão dessa malignidade e conduta de tratamento. Objetivo: O objetivo deste trabalho foi estudar o perfil genético e molecular dos pacientes pediátricos portadores de LLA-T (0-18 anos) através de marcadores clínicos e biológicos que possam contribuir na identificação de fatores de prognóstico da doença. Material e métodos: Participaram do estudo 138 crianças com LLA T, na qual foram utilizadas técnicas de citogenética clássica, bandeamento G e biologia molecular (RT-PCR) para investigação dos achados genéticos dos pacientes. O estudo foi realizado no Instituto Nacional do Câncer, durante o ano de 2015, com material biológico de pacientes que foram diagnosticados entre 2010 e 2015. O programa de hematologia-oncologia pediátricos do Instituto Nacional do Câncer é referência para leucemia aguda, onde são diagnosticadas e tratadas crianças e adolescentes de diversos estados. Desta forma, tem fundamental importância aprimorar o diagnóstico com introdução de técnicas diagnósticas atualizadas, que permitirão definir melhor as características clínicas e laboratoriais e correlaciona-las com a sobrevida e com os dados da literatura, permitindo uma melhor avaliação dos riscos e perfil dos casos de LLA T no Brasil. Resultados: Dos 138 pacientes estudados a maioria foi do sexo masculino (74%) com média de idade de 10 anos. A análise da fusão SIL-TAL1 foi realizada em 70 amostras que obtiveram material suficiente, na qual 13 foram positivas para essa fusão; No HOX11L2, foram possíveis fazer a análise em 71 amostras, sendo duas delas positivas e no MLL/ENL as análises foram realizadas em 92 amostras, 3 delas positivas. Conclusão: De acordo com os achados laboratoriais e clínicos analisados nesse estudo, os resultados encontraram-se coerente aos já encontrados na literatura, sendo que para uma investigação com resultados mais sólidos, faz-se necessário, mas tempo de estudo, sendo que não foi suficiente para alcançar todos os objetivos propostos no início do projeto.
Como Citar
Gueiros, E. B., Oliveira, M. do S. P., Salles, T. de J. M., & Noronha, E. P. (2020). PERFIL CITOGENÉTICO E MOLECULAR DA LEUCEMIA LINFOBLÁSTICA AGUDA EM CÉLULAS T, DE PACIENTES PEDIÁTRICOS. Revista Multidisciplinar Em Saúde , 1 (3), 52. Recuperado de https://editoraime.com.br/revistas/rems/article/view/428
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