ANÁLISE HISTOPATOLÓGICA DA TOXICIDADE AGUDA DA CANNABIS SATIVA

Anthonielle Ingrid Peixoto de  Oliveira; Eduarda Chagas Santos  Brandão; Fernanda Helen Melo da  Costa; Juliane Cabral  Silva; Raquel Teixeira Silva  Celestino

doi:10.51161/rems/3217

ANÁLISE HISTOPATOLÓGICA DA TOXICIDADE AGUDA DA CANNABIS SATIVA

Autores

Anthonielle Ingrid Peixoto de Oliveira
Eduarda Chagas Santos Brandão
Fernanda Helen Melo da Costa
Juliane Cabral Silva
Raquel Teixeira Silva Celestino

DOI:

https://doi.org/10.51161/rems/3217

Palavras-chave:

CANNABIS, TOXICIDADE AGUDA, HISTOLOGIA, PATOLOGIA

Resumo

Introdução: A Cannabis sativa é uma planta utilizada para fins medicinais ou recreativos. No entanto, apesar dos benefícios, ela pode apresentar toxicidade que afeta as condições histológicas do indivíduo conduzindo a alterações patológicas. Objetivo: Analisar na literatura os comprometimentos histopatológicos na toxicidade aguda pelo uso de Cannabis sativa. Material e métodos: Trata-se de uma revisão bibliográfica realizada a partir de buscas na Scientific Electronic Library Online (SciELO), na Biblioteca Virtual em Saúde(BVS) e PubMed com os seguintes Descritores em Ciências da Saúde (DeCS): “(Histology) AND (Cannabis)” para as duas primeiras, enquanto que para PubMed utilizou-se “(Acute Toxicity) AND Cannabis) AND Histology ” AND “Agrochemicals”. Foram identificados 280 artigos durante os últimos 5 anos, sendo excluídos os artigos duplicados e aqueles que não respondessem qual o comprometimento histopatológico nos estudos de toxicidade aguda que utilizaram Cannabis Sativa, bem como revisões, literatura cinzenta, cartas, editoriais, relatos de caso e experiência e os artigos que não se enquadram no período, restando 8 evidências científicas como amostra da pesquisa. Resultados: Identificou-se, após a análise dos artigos, que a toxicidade da Cannabis Sativa está associada a alterações prejudiciais no epitélio seminífero dos testículos com redução significativa no diâmetro, consequente baixos níveis séricos de testosterona e gonadotrofina hipofisária, que provoca espermáticos diminuídos, alta fragmentação de DNA no esperma e fertilidade masculina reduzida. Além disso, mostra-se um aumento da ansiedade e modificações histológicas no tecido adiposo como necrose e inflamação, alterações nos macrófagos intra-alveolares apresentando pigmentados marrons. Ao que se refere ao Sistema nervoso encontram-se pequenas alterações em células, com fragmentação e presença de células picnóticas associadas à redução na densidade neuronal. A exposição à cannabis, especificamente, em gestantes está relacionada a alterações estruturais na retina do feto, deixando-a mais fina e provocando um possível atendimento oftálmico precoce a esse indivíduo. Aponta-se ainda, que durante esse período a exposição à cannabis pode afetar o desenvolvimento do tecido nervoso fetal, causando deficiências neurológicas, hiperatividade, função cognitiva deficiente e alterações nos receptores dopaminérgicos em crianças. Conclusão: Existe uma importante associação entre o uso de Cannabis Sativa, com comprometimento histopatológico de diferentes sistemas do organismo.

Publicado

2022-03-09

Como Citar

Oliveira, A. I. P. de ., Brandão, E. C. S. ., Costa, F. H. M. da ., Silva, J. C. ., & Celestino, R. T. S. . (2022). ANÁLISE HISTOPATOLÓGICA DA TOXICIDADE AGUDA DA CANNABIS SATIVA. Revista Multidisciplinar Em Saúde, 2(4), 34. https://doi.org/10.51161/rems/3217

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

I Congresso On-line Nacional de Histologia e Embriologia Humana

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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