AVALIAÇÃO DOS EFEITOS ADVERSOS DO COMPOSTO MEDICAMENTOSO FOSFATO DE SÓDIO DE BETAMETASONA E DIPROPIONATO DE BETAMETASONA: UMA REVISÃO INTEGRATIVA

Nayane Mayse Barbosa  Silva; Guilherme Rodrigues  Barbosa; Jéssica Sthefanye Urçulino  Dorneles; João Ignácio Oliveira  Uchôa; Marcos Antonio  Eleutério-Silva

doi:10.51161/rems/2614

AVALIAÇÃO DOS EFEITOS ADVERSOS DO COMPOSTO MEDICAMENTOSO FOSFATO DE SÓDIO DE BETAMETASONA E DIPROPIONATO DE BETAMETASONA: UMA REVISÃO INTEGRATIVA

Autores

Nayane Mayse Barbosa Silva
Guilherme Rodrigues Barbosa
Jéssica Sthefanye Urçulino Dorneles
João Ignácio Oliveira Uchôa
Marcos Antonio Eleutério-Silva

DOI:

https://doi.org/10.51161/rems/2614

Palavras-chave:

DIPROPIONATO DE BETAMETASONA, EFEITOS ADVERSOS, FOSFATO DE SÓDIO DE BETAMETASONA

Resumo

Introdução: O composto medicamentoso formado por fosfato de sódio de betametasona (BSP) e dipropionato de betametasona (BDP), glicocorticoides (GC) sintéticos de ação rápida e prolongada, respectivamente, é vastamente utilizado em diversas afecções inflamatórias e alérgicas agudas ou crônicas. Contudo, o uso prolongado deve ser cauteloso, pois embora possua ampla eficácia, efeitos adversos podem ser inevitáveis e permanentes. Objetivo: Avaliar a ocorrência de efeitos adversos decorrentes do uso do composto medicamentoso BSP/BDP. Metodologia: Revisão integrativa com prospecção de artigos pelo PUBMED a partir da palavra-chave: “Betamethasone Dipropionate andBetamethasone Disodium Phosphate” (27 artigos); após exclusão, foram lidos 18 artigos, consensualmente, pelos autores. Resultados e discussão: O composto BSP/BDP está disponível na proporção 5mg/2mg em cada milímetro injetável intramuscular, apresentando ações terapêuticas anti-inflamatórias e antialérgicas. Diferentes estudos apontam importantes resoluções clínicas em doenças como osteoartrite, tendinite, pseudolinfoma cutâneo, miosite, hemangioma, lúpus eritematoso sistêmico, queloide e em outras diferentes doenças autoimunes, musculares e sistêmicas. Contudo, seu uso prolongado pode suprimir o eixo hipotálamo-hipófise-adrenal e comprometer a regulação endógena do cortisol, o que foi demonstrado em estudo recente, registrando-se que a injeção intra-articular do composto medicamentoso para o tratamento de osteoartrite resultou em insuficiência adrenal secundária em 30% dos pacientes. Paralelamente, pesquisadores relataram que 12,3% dos pacientes com hemangioma infantil e que fez uso do BSP/BDP apresentaram atrofia local, úlcera localizada e algumas manifestações semelhantes a Cushing como efeito adverso do composto BSP/BDP. Em outro estudo clínico, observou-se um aumento da glicemia em todos os pacientes com diabetes tipo 2 controlada, submetidos ao tratamento de osteoartrite. Estes efeitos adversos podem ser decorrentes da ação prolongada do BDP, principalmente, quando dose e intervalo entre a administração medicamentosa são ultrapassados. Conclusão: O composto BSP/BDP mostra ser eficaz no tratamento de diversas inflamações e doenças autoimunes, porém alguns pacientes podem apresentar efeitos adversos graves em curto ou longo prazo e deve-se ter cautela quando administrado naqueles com diabetes.

Publicado

2021-11-28

Como Citar

Silva, N. M. B. ., Barbosa, G. R. ., Dorneles, J. S. U. ., Uchôa, J. I. O. ., & Eleutério-Silva, M. A. . (2021). AVALIAÇÃO DOS EFEITOS ADVERSOS DO COMPOSTO MEDICAMENTOSO FOSFATO DE SÓDIO DE BETAMETASONA E DIPROPIONATO DE BETAMETASONA: UMA REVISÃO INTEGRATIVA. Revista Multidisciplinar Em Saúde, 2(4), 178. https://doi.org/10.51161/rems/2614

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

II Congresso Nacional Multidisciplinar em Enfermagem On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
                                                               DAO.retrieveCached(SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2], 3600) % line   91, file: ArticleSearchDAO.inc.php
                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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