MUCORMICOSE EM PACIENTES ACOMETIDOS POR COVID-19: REVISÃO INTEGRATIVA DA LITERATURA

Luanna Paula Garcez de Carvalho  Feitoza; Anna Ellen Marques De  Lima; Júlia Resende  Rissari; Samia Walid Ali  Saleh; Fabiane Veloso  Soares

doi:10.51161/rems/2162

MUCORMICOSE EM PACIENTES ACOMETIDOS POR COVID-19: REVISÃO INTEGRATIVA DA LITERATURA

Autores

Luanna Paula Garcez de Carvalho Feitoza
Anna Ellen Marques De Lima
Júlia Resende Rissari
Samia Walid Ali Saleh
Fabiane Veloso Soares

DOI:

https://doi.org/10.51161/rems/2162

Palavras-chave:

COVID, FUNGO, ZIGOMICOSE, INFECÇÃO

Resumo

Introdução: A Mucormicose (zigomicose) é uma patologia infectocontagiosa oportunista rara causada por fungos da ordem Mucorales, com incidência em diabéticos em cetoacidose, pacientes imunodepressivos sob quimioterapia por doenças neoplásicas, pós-transplantados e também sob aqueles com corticoterapia prolongada, como pacientes da COVID-19. O subtipo clínico rino-orbital-cerebral é o mais frequente (44% a 49%) dos casos relatados. No contexto da pandemia causada pelo SARS-CoV2, têm-se evidenciado casos de mucormicose associados a essa patologia, pois devido a inflamação robusta e a imunossupressão simultânea (sobretudo em pacientes com morbidades como o Diabetes Mellitus) evidentes no manejo da COVID-19, acredita-se que a resposta imune desregulada fornece um hospedeiro propício ao desenvolvimento de infecções fúngicas. Sua sintomatologia depende de onde o fungo está crescendo no corpo e seu diagnóstico é baseado nos achados clínicos e de imagem, juntamente com a associação de fatores de risco potenciais. A terapêutica consiste em retirada cirúrgica de tecidos necrosados e antifúngicos. Objetivo: Averiguar na literatura científica a Mucormicose e sua relação oportunística em pacientes acometidos por COVID-19. Material e métodos: Revisão Integrativa da Literatura com dados coletados nas bases de dados PUBMED, SCIENCE DIRECT e SPRINGER LINK a partir de 2020. A análise dos dados incluiu a pré-análise, tratamento dos dados e interpretação dos resultados. Resultados: Foram incluídos oito estudos científicos, sendo notado que a mucormicose decorrente de pacientes com COVID-19 foi mais comumente observada em pacientes com história de diabetes mellitus e com COVID-19 grave ou crítico em pacientes na Índia. No Irã, um estudo multicêntrico também mostra que 86% dos pacientes com COVID-19 e mucormicose apresentavam diabetes mellitus e 46,6% receberam terapia com corticosteróide. Neste ano o Ministério da Saúde brasileiro registrou 49 casos de mucormicose, sendo 19 pacientes com COVID-19 e a maioria apresentava diabetes mellitus. Esses dados não representam o total de registros da doença no Brasil e sim casos que chegam ao conhecimento do órgão por meio da solicitação de medicamentos ou pelos CIEVS locais. Conclusão: A imunossupressão causada pela infecção da COVID-19 concomitante a sua terapêutica por meio da corticoterapia e comorbidades anteriores tornou pacientes mais suscetíveis a infecções fúngicas secundárias, como a mucormicose.

Publicado

2021-10-07

Como Citar

Feitoza, L. P. G. de C. ., Lima, A. E. M. D. ., Rissari, J. R. ., Saleh, S. W. A. ., & Soares, F. V. . (2021). MUCORMICOSE EM PACIENTES ACOMETIDOS POR COVID-19: REVISÃO INTEGRATIVA DA LITERATURA. Revista Multidisciplinar Em Saúde, 2(4), 21. https://doi.org/10.51161/rems/2162

Baixar Citação

Edição

v. 2 n. 4 (2021)

Seção

I Congresso Brasileiro de Doenças Infectocontagiosas On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
                                                               DAO.retrieveCached(SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2], 3600) % line   91, file: ArticleSearchDAO.inc.php
                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php