Início
/
Arquivos
/
v. 2 n. 3 (2021)
/
I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais
A QUIMIOTERAPIA METRONÔMICA NO TRATAMENTO DE NEOPLASIAS MAMÁRIAS
Autores
Mirthys Alana Trajano da Silva Melo
Thiago Emannuel Pessoa Da Silva
Luiza Smith Branquinho
Rebecca Francinny Silva Oliveira Pacheco
Julya Myrrha Jenuino Feitosa Barroca
Palavras-chave:
ANIMAIS DE ESTIMAÇÃO, NEOPLASIAS MAMÁRIAS ANIMAIS, PROTOCOLOS ANTINEOPLÁSICOS
Resumo
Introdução: Neoplasias mamárias são as principais responsáveis pela mortalidade em animais de companhia. Um dos tratamentos é feito com a administração de fármacos citotóxicos que induzem danos químicos as células neoplásicas. A terapia mais utilizada segue o conceito da dose máxima tolerada (DMT) pelo paciente, tratamento este, cujos intervalos entre as doses favorece a regeneração das células endoteliais, permitindo a persistência da angiogênese tumoral. A Quimioterapia Metronômica (QM) consiste na observação dos agentes citotóxicos convencionais, administrados em baixas dosagens, exercendo efeitos antiangiogênicos, tornando-se uma alternativa pioneira viável para o tratamento de neoplasias mamárias, sendo um método de baixo custo que promove efeitos colaterais menores quando comparada a DMT. Objetivo: Analisar as implicações da QM em relação a terapia (DMT) no tratamento das neoplasias mamárias. Materiais e métodos: O presente estudo trata-se de uma revisão de literatura com base em dados adquiridos do Instituto Nacional do Câncer e Google Acadêmico. A pesquisa foi realizada a partir dos termos Quimioterapia animal, Quimioterapia Metronômica, Tratamento de câncer em animais e Quimioterapia convencional. Critérios para inclusão foram ano de publicação (2008 a 2016), ser do idioma português e os critérios de exclusão foram fuga parcial ou total aos objetivos da pesquisa e acesso pago. Resultados: Para amenizar os danos, efeitos colaterais e intervalos de tempo promovidos pela DMT, desenvolveram-se alternativas como a QM. O uso dessa terapia elimina longos períodos entre doses, diminuindo as chances de surgir alterações oportunistas nas células tumorais. O tratamento dos carcinomas mamários é feito pela administração oral de Ciclofosfamida em regime de QM através da ingestão do fármaco em baixa quantidade. Diferente da DMT que é realizada de maneira intravenosa. Evidências sugerem que a ciclofosfamida em regime de QM em cães e gatos, mostrou-se mais eficiente no tratamento de carcinomas mamários, em relação aos outros cânceres, devido ao seu efeito antigiogênico sobre as células tumorais. Conclusão: A comparação entre o tratamento com a terapia convencional e a terapia metronômica, mostrou que a QM é tão eficaz quanto a quimioterapia tradicional (DMT). Porém, a DMT ainda possui uma maior aplicabilidade, devido seus estudos e utilização mais prevalentes no campo veterinário.
Como Citar
Melo, M. A. T. da S., Silva, T. E. P. D., Branquinho, L. S., Pacheco, R. F. S. O., & Barroca, J. M. J. F. . (2021). A QUIMIOTERAPIA METRONÔMICA NO TRATAMENTO DE NEOPLASIAS MAMÁRIAS. Revista Multidisciplinar Em Saúde , 2 (3), 09. https://doi.org/10.51161/rems/1821
Seção
I Congresso On-line Nacional de Clínica Veterinária de Pequenos Animais
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
ADOConnection.CacheExecute(3600, SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2]) % line 132, file: DAO.inc.php
DAO.retrieveCached(SELECT o.submission_id, MAX(s.context_id) AS journal_id, MAX(i.date_published) AS i_pub, MAX(p.date_published) A..., Array[2], 3600) % line 91, file: ArticleSearchDAO.inc.php
ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line 201, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line 194, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line 146, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line 132, file: SubmissionSearch.inc.php
SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line 263, file: SubmissionSearch.inc.php
SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line 92, file: RecommendBySimilarityPlugin.inc.php
RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line 107, file: HookRegistry.inc.php
HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line 43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line 123, file: smarty_template_resource_base.php
Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line 114, file: smarty_template_compiled.php
Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line 216, file: smarty_internal_template.php
Smarty_Internal_Template.render(false, 1) % line 232, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line 134, file: smarty_internal_templatebase.php
Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line 924, file: PKPTemplateManager.inc.php
PKPTemplateManager.display(frontend/pages/article.tpl) % line 292, file: ArticleHandler.inc.php
ArticleHandler.view(Array[1], Object:Request) % line 391, file: PKPRouter.inc.php
PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line 231, file: PKPPageRouter.inc.php
PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
Artigos Semelhantes
Você também pode iniciar uma pesquisa avançada por similaridade para este artigo.