Início
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Arquivos
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v. 2 n. 3 (2021)
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I Congresso Nacional Multidisciplinar de Oncologia On-line
RELAÇÃO ENTRE HEMOCROMATOSE HEREDITÁRIA E A INCIDÊNCIA DE CARCINOMA HEPATOCELULAR
Autores
Sérgio Antônio Murad Neto
Carollayne Mendonça Rocha
Helena Da Silva Mendonça
Maria Eduarda Siqueira De Oliveira
Alessandra Dos Santos Danziger Silvério
Palavras-chave:
CIRROSE, NEOPLASIAS HEPÁTICAS, SOBRECARGA DE FERRO
Resumo
Introdução: A Hemocromatose hereditária (HH) é uma mutação autossômica recessiva que resulta em sobrecarga de ferro. Sabe-se que essa alteração no metabolismo do ferro é causa de diversas doenças que levam seus portadores ao óbito, entre elas tem-se cirrose, diabetes, insuficiência cardíaca congestiva e carcinoma hepatocelular (CHC). Objetivos: Identificar evidências na literatura sobre a relação entre hemocromatose hereditária e a incidência de carcinoma hepatocelular. Metodologia: Através de uma revisão integrativa de literatura, encontrou-se 363 artigos nas bases de dados Pubmed, Scielo e Lilacs com o uso dos descritores contidos no Descritores em Ciências da Saúde: “Iron Overload”, “Hepatocellular Carcinoma” e “Hemochromatosis”. Foram incluídos artigos oriundos de ensaios clínicos, artigos originais, estudos observacionais e de avaliação, publicados nos anos de 2015 a 2021, nos idiomas inglês e português. Excluiu-se artigos desenvolvidos a partir de testes em animais. Resultados: A homozigose para o polimorfismo CP282Y do gene HFE demonstrou-se como um potente fator para a predisposição ao risco de neoplasias hepáticas. Os estudos mostram que a sobrecarga e deposição de ferro nas células hepáticas gera fibrose avançada e cirrose, que são as principais causas de CHC. Foi constatado que alguns pacientes com HH, principalmente quando não tratada, podem desenvolver o carcinoma hepatocelular, mesmo sem a presença da cirrose. Além disso, indivíduos com HH têm um risco a longo prazo de 20 a 200 vezes maior de desenvolver o CHC, devido a deposição de ferro no tecido hepático e a presença de radicais livres, como a hidroxila, que aumentam a incidência de câncer. Conclusão: A hemocromatose hereditária aumenta significativamente as chances de o indivíduo desenvolver o CHC o qual é umas das principais causas de morte prematura nos portadores dessa condição.
Como Citar
Neto, S. A. M. ., Rocha, C. M. ., Mendonça, H. D. S. ., Oliveira, M. E. S. D. ., & Silvério, A. D. S. D. . (2021). RELAÇÃO ENTRE HEMOCROMATOSE HEREDITÁRIA E A INCIDÊNCIA DE CARCINOMA HEPATOCELULAR. Revista Multidisciplinar Em Saúde , 2 (3), 16. https://doi.org/10.51161/rems/1544
Seção
I Congresso Nacional Multidisciplinar de Oncologia On-line
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Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php
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