TERAPIA COMBINADA COM QUIMIOTERÁPICOS E SEUS EFEITOS CARDIOTOXICOS NO TRATAMENTO DE PACIENTES ONCOLÓGICOS

Autores

  • Ediran Ericles Pontes dos Anjos
  • Elivelton Pontes Dos Anjos
  • Andre Diego Xavier Spinola

DOI:

https://doi.org/10.51161/rems/1541

Palavras-chave:

CARDIOTOXICIDADE EM PACIENTES ONCOLÓGICOS, EFEITOS ADVERSOS NA TERAPIA COMBINADA COM QUIMIOTERÁPICOS, QUIMIOTERÁPICOS.

Resumo

Introdução: Os medicamentos quimioterápicos são amplamente utilizados na prática clínica, visando destruir a multiplicação desordenada de células tumorais com sua ação de toxicidade durante a sua fase terapêutica. Além disso, sua finalidade é promover o efeito paliativo de patologias como o câncer. No entanto, indivíduos que estão mais expostos a este tipo de droga, ou que fazem o uso combinado com outros quimioterápicos, podem apresentar risco de cardiotoxicidade comprometendo as funções cardiovasculares. Objetivo: O presente trabalho teve como objetivo analisar os efeitos cardiotóxicos dos quimioterápicos em indivíduos que fazem o uso da substância no tratamento do câncer. Método: Trata-se de uma revisão bibliográfica integrativa, foram realizadas pesquisas nas bases de dados PubMed, SciElo nas línguas portuguesa e inglesa entre 2015 a 2020. Fez-se a inclusão de termos durante as buscas sobre os efeitos cardiotóxicos dos quimioterápicos em pacientes oncológicos. Resultados: No período analisado desse estudo, observou-se os efeitos cardiotóxicos nestes indivíduos. Após esta análise, as primeiras evidências indicaram possíveis alterações na disfunção sistólica do ventrículo esquerdo, relacionada as doses cumulativas da substância, causando uma elevada incidência de disfunção cardíaca, acima do permitido, em doentes com cancro. Outro ponto importante a ser destacado, é que em uma terapia combinada com os seguintes fármacos: capecitabina, 5-fluoracilo (5-fu) e bevacizumab. Observou-se o surgimento da doença coronária, associado ao uso de outros quimioterápicos. Conclusão: Desse modo, é necessário que seja definido normas seguras na administração do medicamento em terapia combinada com outros quimioterápicos. afim de minimizar os efeitos cardiotóxicos durante a fase de tratamento de pacientes oncológicos. Visto isso, é importante que novos estudos sejam realizados, com intuito de evitar possíveis efeitos adversos na terapia combinada com os quimioterápicos, mudando o diagnóstico final do paciente.

Publicado

2021-07-28

Como Citar

Anjos, E. E. P. dos ., Anjos, E. P. D. ., & Spinola, A. D. X. . (2021). TERAPIA COMBINADA COM QUIMIOTERÁPICOS E SEUS EFEITOS CARDIOTOXICOS NO TRATAMENTO DE PACIENTES ONCOLÓGICOS. Revista Multidisciplinar Em Saúde, 2(3), 13. https://doi.org/10.51161/rems/1541

Edição

v. 2 n. 3 (2021)

Seção

I Congresso Nacional Multidisciplinar de Oncologia On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php