MECANISMOS DE RESISTÊNCIA AOS ANTIBIÓTICOS BETALACTÂMICOS PELOS STAPHYLOCOCCUS AUREUS

Lohraine Talia  Domingues; Mariana Kely Diniz Gomes De  Lima; Paulo Schumann  Neto; Isabela Reis  Manzoli; Diego Bezerra  Soares

doi:10.51161/rems/1446

MECANISMOS DE RESISTÊNCIA AOS ANTIBIÓTICOS BETALACTÂMICOS PELOS STAPHYLOCOCCUS AUREUS

Autores

Lohraine Talia Domingues
Mariana Kely Diniz Gomes De Lima
Paulo Schumann Neto
Isabela Reis Manzoli
Diego Bezerra Soares

DOI:

https://doi.org/10.51161/rems/1446

Palavras-chave:

ANTIBIÓTICOS BETALACTÂMICOS, RESISTÊNCIA, STAPHYLOCOCCUS AUREUS

Resumo

Introdução: A bactéria Staphylococcus aureus é uma das mais perigosas infecções estafilocócicas resistentes a antibióticos, sobretudo porque possui alta capacidade de virulência, liberação de toxinas e conseguem se disseminar rapidamente nas regiões cutâneas, pulmonares, válvulas cardíacas e ósseas. Ademais, essas bactérias são classificadas como gram-positivas, em forma de esferas (cocos) que podem provocar espinhas e furúnculos, inclusive acometimentos mais graves, como pneumonia, meningite, endocardite, síndrome do choque tóxico e septicemia. Objetivos: Devido a elevada prevalência no número de casos e a resistência aos antibióticos betalactâmicos essa doença pode ser considerada de grande relevância ao estudo médico. Nesse contexto, são necessários mais estudos que esclareçam a padronização dessa patologia. Com isso, foi levantado a seguinte problemática: “Quais seriam os mecanismos de resistência aos antibióticos betalactâmicos pelos Staphylococcus aureus?”. Material e Métodos: A pesquisa consiste em uma revisão de literatura retrospectiva, com o objetivo de entender os aspectos de resistência aos antibióticos betalactâmicos pelos Staphylococcus aureus. Resultados: A partir desse estudo foi possível observar que as bactérias por meio da alta capacidade de replicação, conseguiram produzir algumas enzimas e estruturas que conferem um fator de resistência aos antibióticos, tais como: aderência, a cápsula de ácido hialurônico, a proteína M e outras enzimas. Nesse sentido, a enzima que mais se destaca é a betalactamase que é capaz de inibir a ação dos antibióticos betalactâmicos favorecendo ainda mais a patogenicidade durante a infecção. Conclusão: Por meio desse estudo, observou-se acentuada resistência bacteriana do Staphylococcus aureus através da capacidade de produzir enzimas principalmente a betalactamase responsável pelo fator de inviabilização dos antibióticos betalactâmicos.

Publicado

2021-07-28

Como Citar

Domingues, L. T. ., Lima, M. K. D. G. D. ., Neto, P. S. ., Manzoli, I. R., & Soares, D. B. . (2021). MECANISMOS DE RESISTÊNCIA AOS ANTIBIÓTICOS BETALACTÂMICOS PELOS STAPHYLOCOCCUS AUREUS. Revista Multidisciplinar Em Saúde, 2(3), 44. https://doi.org/10.51161/rems/1446

Baixar Citação

Edição

v. 2 n. 3 (2021)

Seção

II Congresso Brasileiro de Saúde On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

                                                                  ADOConnection.CacheExecute(3600, SELECT 				o.submission_id, 				MAX(s.context_id) AS journal_id, 				MAX(i.date_published) AS i_pub, 				MAX(p.date_published) A..., Array[2]) % line  132, file: DAO.inc.php
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                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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