O  DIABETES MELLITUS TIPO-I ALTERA A MORFOLOGIA DE GLÂNDULAS SALIVARES

Shirley Aparecida Azevedo  Borges; Ieda Carla  Candido; Jaqueline Carvalho  Rinaldi; Joice Toracci  Alves

doi:10.51161/rems/1428

O DIABETES MELLITUS TIPO-I ALTERA A MORFOLOGIA DE GLÂNDULAS SALIVARES

Autores

Shirley Aparecida Azevedo Borges
Ieda Carla Candido
Jaqueline Carvalho Rinaldi
Joice Toracci Alves

DOI:

https://doi.org/10.51161/rems/1428

Palavras-chave:

ESTROMA, HISTOLOGIA, PARÊNQUIMA

Resumo

Introdução: A diabetes mellitus tipo 1 (DMT1) é uma doença metabólica, caracterizada pela destruição das células beta pancreáticas, levando a hiperglicemia crônica. Nas glândulas salivares pode provocar danos teciduais e prejuízo na produção de saliva. Objetivo: Este estudo tem como objetivo investigar se o DM1 altera a morfologia das glândulas salivares parótida e sublingual e submandibular. Materiais e métodos: Foram distribuídos 12 ratos Wistar adultos (250g) nos grupos: controle ou NG (normoglicêmico, n=6) e diabético ou DM1 (n=6). O DM1 foi induzido por injeção endovenosa de estreptozootocina (55 mg/kg de peso corporal) sendo considerados diabéticos os animais com glicemia de jejum e pós-prandial ≥ 300 mg/dL. Os animais foram eutanasiados 30 dias após a indução. As glândulas salivares foram dissecadas, pesadas, desidratadas em etanol, diafanizadas em xilol e emblocadas em parafina. Cortes de 5um foram corados em hematoxilina e eosina para análise histopatológica. O método de Weibel foi utilizado para analisar a proporção entre os compartimentos glandulares. Os dados foram submetidos a análise estatística pelo teste t e foi considerado significativo valores de p<0,05. Resultado: Dentre os principais resultados encontrados, pode-se listar a perda de polaridade das células epiteliais, vacuolização celular e diferença de distribuição entre os compartimentos glandulares. Conclusão: Conclui-se que o DM-1 alterou a morfológicas dos acinos e ductos das glândulas salivares.

Publicado

2021-07-28

Como Citar

Borges, S. A. A. ., Candido, I. C. ., Rinaldi, J. C. ., & Alves, J. T. . (2021). O DIABETES MELLITUS TIPO-I ALTERA A MORFOLOGIA DE GLÂNDULAS SALIVARES. Revista Multidisciplinar Em Saúde, 2(3), 26. https://doi.org/10.51161/rems/1428

Baixar Citação

Edição

v. 2 n. 3 (2021)

Seção

II Congresso Brasileiro de Saúde On-line

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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