ZEBRAFISH (Danio rerio): NOVO MODELO ANIMAL INTRODUZIDO COM ÊXITO NO CENÁRIO CIENTÍFICO

Mayara  Couto Santos; Eldevan  Santos Silva; Ana Maria  Fernandes Menezes; Letícia  Pimenta Banax Junqueira; Luis Otávio  Da Silva Rodrigues

ZEBRAFISH (Danio rerio): NOVO MODELO ANIMAL INTRODUZIDO COM ÊXITO NO CENÁRIO CIENTÍFICO

Autores

Mayara Couto Santos
Eldevan Santos Silva
Ana Maria Fernandes Menezes
Letícia Pimenta Banax Junqueira
Luis Otávio Da Silva Rodrigues

Palavras-chave:

Modelo animal, Pesquisa, Inovação, Zebrafish

Resumo

Introdução: A maioria das pesquisas médicas necessita de modelos animais para ampliar o conhecimento sobre as causas e consequências das doenças humanas, possibilitando com isso novos testes e terapias inovadoras. Apesar dos roedores serem frequentemente utilizados, o Zebrafish é um vertebrado que foi introduzido com êxito no cenário científico, constituindo um excelente modelo experimental para estudo de diversas doenças e testar novos agentes terapêuticos. Objetivo: O objetivo do estudo foi mostrar a importância do Zebrafish como modelo animal no cenário científico. Material e métodos: Trata-se de um estudo exploratório, realizado por meio de uma pesquisa bibliográfica. Realizou-se buscas nas bases PubMed e Web of Science. Foram selecionados 8 artigos que atenderam aos critérios de inclusão. Resultados: O Zebrafish é um pequeno teleósteo tropical de água doce introduzido na ciência na década de 80 pelo biólogo George Streisinger da University of Oregon (USA). Seus estudos revolucionários permitiram que os cientistas realizassem experimentos no Zebrafish, antes possíveis apenas em invertebrados. O Zebrafish tem substituído os roedores na pesquisa, pois apresenta baixo custo de reprodução, fertilização externa, geneticamente manipulável e com genoma sequenciado com homologia com os mamíferos. Além disso, seu desenvolvimento ocorre até 72 horas após fertilização e com embrião transparente durante todo seu desenvolvimento, permitindo acompanhar as mutações, em tempo real ao ser manipulado por estratégias farmacológicas ou de bloqueio gênico. Em estudos comportamentais, o Zebrafish se destaca na análise da resposta de medo e condições psicopatológicas como a ansiedade, devido a sua conservação genética e comportamentos característicos, sendo um modelo bem estabelecido em pesquisas neurocomportamentais. Conclusão: É notória a importância do uso do Zebrafish como organismo experimental de pesquisas científicas, sendo utilizado em inúmeras áreas como neurofisiologia, genéticas e toxicologia, além de aplicações na indústria farmacêutica, acelerando o processo de testes de novas drogas.

Publicado

2020-04-01

Como Citar

Couto Santos, M. ., Santos Silva, E., Fernandes Menezes , A. M. ., Pimenta Banax Junqueira, L., & Da Silva Rodrigues, L. O. . (2020). ZEBRAFISH (Danio rerio): NOVO MODELO ANIMAL INTRODUZIDO COM ÊXITO NO CENÁRIO CIENTÍFICO. Revista Multidisciplinar Em Saúde, 1(1), 34. Recuperado de https://editoraime.com.br/revistas/rems/article/view/119

Baixar Citação

Edição

v. 1 n. 1 (2020): Edição Especial: Anais do I Congresso Brasileiro de Ciências Farmacêuticas On-line

Seção

Anais de Evento

Licença

Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php