Início
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Arquivos
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v. 2 n. 2 (2021): Edição Especial: Anais de Eventos
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Anais do I Congresso Nacional de Microbiologia Clínica On-Line
AVALIAÇÃO DE MÉTODO COMERCIAL PARA DOSAGEM DE VANCOCINEMIA EM PACIENTES SOB TERAPIA DE SUBSTITUIÇÃO RENAL
Autores
Letícia Vale Scribel
Rafael Linden
Alexandre Zavascki
Roberta Zilles Hahn
Cristina Boff Castro De Araujo
Palavras-chave:
VANCOMICINA, CDP-1, MONITORAMENTO TERAPÊUTICO, CMIA, LC-MS/MS
Resumo
Introdução: A vancomicina é um antibiótico amplamente utilizado como tratamento para infecções causadas por bactérias gram positivas como Staphylococcus aureus resistente à meticilina (MRSA). Diferentes ensaios estão disponíveis para quantificar o nível sérico da vancomicina (vancocinemia), entretanto alguns estudos reportam a interferência do produto de degradação chamado de CDP-1 (Crystalline Degradation Product ) nos imunoensaios, resultando em valores de vancocinemia superestimados quando comparados com o método de Cromatografia Líquida acoplada à Espectrometria de Massas em Sequência (LC-MS/MS). Uma vez que vancomicina é excretada pelos rins, pacientes com insuficiência renal podem acumular CDP-1. A superestimativa dos níveis séricos de vancomicina induz o médico assistente a reduzir a dose prescrita para o paciente, resultando em níveis subterapêuticos com risco de desenvolvimento de resistência bacteriana e de falha terapêutica. Assim, a quantificação precisa da vancocinemia é importante para o monitoramento terapêutico. Objetivo: Este estudo visa comparar o método CMIA (imunoensaio de micropartículas por quimioluminescência) com o método LC-MS/MS para a dosagem de vancomicina em pacientes sob terapia de substituição renal. Material e métodos: Foram selecionados pacientes internados no Hospital de Clínicas de Porto Alegre em uso de vancomicina e sob terapia de substituição renal no período de dezembro de 2020 a março de 2021. As amostras de soro foram analisadas pelos métodos CMIA e LC-MS/MS. A concordância entre os dois métodos foi avaliada utilizando a análise de regressão de Passing-Bablok, com 95% de intervalo de confiança (95% IC). Resultados: Foi analisada a vancocinemia de 55 amostras de soro coletadas de 22 pacientes que estavam sob terapia de substituição renal durante o tratamento. Os resultados obtidos pelos dois métodos foram altamente correlacionados (r = 0.913). Não foram observados desvio da linearidade (P = 0,92), diferença sistemática (intercepto = 1,7901; -0,6764 a 4,0302; IC=95%) tampouco diferença proporcional (coeficiente de inclinação =0,9223; 0,7938 a 1,0730; IC=95%). Conclusão: As concentrações de vancomicina obtidas por CMIA e LC-MS/MS são altamente correlacionadas em pacientes sob terapia de substituição renal. Assim, a LC-MS/MS apresentou-se como valiosa alternativa à CMIA em pacientes com perda de função renal.
Como Citar
Scribel , L. V., Linden, R., Zavascki, A. ., Hahn, R. Z. ., & Araujo, C. B. C. D. . (2021). AVALIAÇÃO DE MÉTODO COMERCIAL PARA DOSAGEM DE VANCOCINEMIA EM PACIENTES SOB TERAPIA DE SUBSTITUIÇÃO RENAL. Revista Multidisciplinar Em Saúde , 2 (2), 18. https://doi.org/10.51161/rems/1175
Seção
Anais do I Congresso Nacional de Microbiologia Clínica On-Line
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PKPPageRouter.route(Object:Request) % line 143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line 281, file: PKPApplication.inc.php
PKPApplication.execute() % line 68, file: index.php