SARS-COV-2 E LESÃO CARDÍACA: A RELAÇÃO ENTRE BIOMARCADORES E PROGNÓSTICO

Autores

  • Rafael Xavier Cunha
  • ISABELA ABUD DE ANDRADE
  • JOANA BADER SADALA BRANDÃO
  • MARIA EDUARDA ALENCAR SANTOS
  • PAULA CRISTINA RIOS RODRIGUEZ

DOI:

https://doi.org/10.51161/rems/1118

Palavras-chave:

BIOMARCADORES CARDÍACOS, INFECÇÕES POR CORONAVÍRUS, LESÃO CARDÍACA

Resumo

INTRODUÇÃO: A pandemia causada pelo novo coronavírus tornou-se o epicentro dos esforços em estudos científicos a fim de compreender os mecanismos fisiopatológicos que levam a desfechos, em muitos casos, tão graves. É sabido que a presença da enzima conversora da angiotensina 2 (ECA2) presente em vários órgãos como rins, fígado, pulmões e coração levanta um alerta para o potencial causador de falência múltipla de órgãos. A partir do conhecimento prévio desse potencial de lesão em vários órgãos, foram realizados estudos a fim de compreender qual o papel que a infecção pelo Sars-CoV-2 desempenha na lesão cardíaca. OBJETIVO: Compreender as relações dos biomarcadores de lesão cardíaca a fim de alertar sobre a importância da avaliação cardíaca dos pacientes com Covid-19. MÉTODO: Foi realizado um levantamento bibliográfico nas bases de dados PubMed e SciELO, selecionando artigos publicados entre 2019 e 2021, com adoção de palavras chaves como “COVID-19”, “marcadores cardíacos” e “lesão cardíaca”. RESULTADOS: A lesão cardíaca aguda está diretamente relacionada à gravidade da Covid-19 e associada a um risco de mortalidade 4 vezes maior. Marcadores cardíacos, como CK-MB, NT-proBNP e troponina I, indicam lesão cardíaca durante a infecção pelo novo coronavírus. É sabido que o aumento dos níveis séricos desses biomarcadores em pacientes com Covid-19 advém de um cenário de intensas lesões celulares do miocárdio, tendo como fatores causais a hipoxemia e reação intensa do sistema imune em resposta a chuva de citocinas gerada pela ação viral. Estudos apontam que a troponina I está mais elevada em pacientes infectados com Sars-CoV-2 em quadro grave quando comparados aos quadros leves, apresentando um risco 80% maior de morte. Além disso, evidenciou-se casos de tamponamento cardíaco e miocardite fulminante após infecção por Covid19. Avaliações de mudanças dinâmicas em hsTnl e NT-proBNP mostram elevação dos biomarcadores de lesão cardíaca durante o período de hospitalização e elevação imediata após a morte, sugerindo danos cardíacos preexistentes a síndrome de disfunção de diversos órgãos. CONCLUSÃO: Conclui-se a necessidade de medição longitudinal de biomarcadores de danos cardíacos, proporcionado a descoberta de um subgrupo de pacientes com dano cardíaco e, dessa forma, prever progressão de Covid-19 para um quadro grave.

Publicado

2021-05-03

Como Citar

Cunha, R. X. ., DE ANDRADE, I. A. ., BRANDÃO, J. B. S. ., SANTOS, M. E. A., & RODRIGUEZ, P. C. R. . (2021). SARS-COV-2 E LESÃO CARDÍACA: A RELAÇÃO ENTRE BIOMARCADORES E PROGNÓSTICO. Revista Multidisciplinar Em Saúde, 2(2), 69. https://doi.org/10.51161/rems/1118

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Imunologia On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br


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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                            ArticleSearchDAO.getPhraseResults(Object:Journal, Array[1], null, null, , 500, 1) % line  201, file: SubmissionSearch.inc.php
                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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