COLITE PSEUDOMEMBRANOSA CAUSADA PELO USO DE ANTIMICROBIANOS NO ÂMBITO HOSPITALAR

Autores

  • Adna Vasconcelos Fonteneles
  • Fabio Frota de Vasconcelos
  • Alana Cavalcante dos Santos
  • Renan Rhonalty Rocha

Palavras-chave:

Clostridioides difficile, Diarreia, Farmácia clínica

Resumo

INTRODUÇÃO: A colite pseudomembranosa é causa de diarreia associada ao uso de antibióticos, sendo provocada por reação inflamatória intestinal às toxinas do Clostridioides difficile. OBJETIVO: Verificar o manejo clínico da colite pseudomembranosa no ambiente hospitalar. MATERIAL E MÉTODO: Trata-se de uma revisão integrativa baseando-se nos dados contidos em artigos publicados entre 2011 e 2019, dispostos nas bases de dados de pesquisas BVS, PubMed, LILACS, Medline. Foram utilizados os descritores “colite pseudomembranosa”, “manejo hospitalar” e “antimicrobianos” com operador booleano “AND”, tendo como critérios de inclusão: artigos completos que abordam o tema, publicados em inglês e português, entre 2013 e 2019; já os critérios de exclusão são: artigos repetidos, que não seja inglês ou português, que não abordem o tema e que sejam publicados antes do ano de 2013. RESULTADOS: Encontrou-se 5 publicações científicas, no qual verificou-se o manejo em casos de colite pseudomembranosa por uso de antimicrobianos. Embora a maioria dos antibióticos tenha sido implicada, os medicamentos que apresentam o maior risco são as Cefalosporinas (particularmente de 3ª geração), Penicilinas (particularmente ampicilina e amoxicilina), Clindamicina e Fluoroquinolonas. Em alguns casos são resolvidos com a descontinuação do antibiótico. Os dois principais antibióticos utilizados para tratamento de infecção por são o metronidazol e a vancomicina. A vancomicina não é mais considerada terapia de primeira escolha para, pois apresenta a mesma eficácia que o metronidazol, o custo é mais elevado e há risco, durante a terapia, de surgimento de Enterococcus spp. resistentes à vancomicina. É indicada apenas nos pacientes com quadros graves ou em pacientes que apresentam recidiva. Orienta-se evitar o uso de agentes antiperistálticos, monitorar e corrigir anormalidades eletrolíticas e pode-se considerar a profilaxia farmacológica do tromboembolismo venoso. CONCLUSÃO: A colite pseudomembranosa é uma enfermidade grave que pode ser prevenida evitando-se o uso indiscriminado de antibióticos.

Publicado

2020-04-01

Como Citar

Vasconcelos Fonteneles, A. ., Frota de Vasconcelos, F. . ., Cavalcante dos Santos, A. ., & Rhonalty Rocha, R. . (2020). COLITE PSEUDOMEMBRANOSA CAUSADA PELO USO DE ANTIMICROBIANOS NO ÂMBITO HOSPITALAR. Revista Multidisciplinar Em Saúde, 1(1), 16. Recuperado de http://editoraime.com.br/revistas/rems/article/view/101

Edição

v. 1 n. 1 (2020): Edição Especial: Anais do I Congresso Brasileiro de Ciências Farmacêuticas On-line

Seção

Anais de Evento

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php