UMA ANÁLISE SOBRE A RELAÇÃO DA DOENÇA DO CORONAVÍRUS COM O LÚPUS ERITEMATOSO SISTÊMICO

Autores

  • Bruna de oliveira Batista
  • THIAGO JOSE FARIAS DA FONSECA SANTOS
  • HERLEM MARIA GONÇALVES

DOI:

https://doi.org/10.51161/rems/1017

Palavras-chave:

CORONAVÍRUS, LÚPUS ERITEMATOSO SISTÊMICO, SUSCETIBILIDADE

Resumo

Introdução:A doença do coronavírus é uma infecção viral gerada pela Síndrome Respiratória Aguda Grave (SARS) ligada ao SARS-CoV-2 (coronavírus 2). Embora não esteja comprovada a relação de suscetibilidade de Lúpus Eritematoso Sistêmico (LES) com o COVID-19, pesquisas afirmam que pacientes portadores de LES estão mais propensos a manifestações graves da doença. Além disso, há casos de indivíduos sem doenças autoimunes que manifestaram sinais clínicos do lúpus após a infecção pelo vírus (LIU; SAWALHA; LU, 2021). Objetivos - Realizar uma análise sobre a relação entre a doença do coronavírus e o Lúpus Eritematoso Sistêmico (LES).Material e métodos:Foi realizada a uma revisão bibliográfica sobre o tema nas revistas acadêmicas científicas online disponíveis nas plataformas do Scielo, Pubmed e Biblioteca Virtual em Saúde (BVS), reunindo e comparando as diferentes informações encontradas a fim de analisar a relação entre COVID-19 e Lúpus Eritematoso Sistêmico. Resultados: A suposta suscetibilidade pode ser explicada através do estresse oxidativo causado por infecções virais, que aumentam o defeito de metilação do DNA no lúpus, resultando em bastante hipometilação, superexpressão da proteína ACE-2 e maior viremia. Ademais, a desmetilação de genes regulados por interferon, NFκB e citocinas em indivíduos com lúpus pode exacerbar a resposta imune à infecção e elevar os níveis de citocina. Tais fatores facilitam a entrada do vírus no organismo e levam a uma resposta imunológica exacerbada (SAWALHA et al, 2020). Paralelamente, há relatos de pacientes que desenvolveram lúpus eritematoso sistêmico após a infecção pelo vírus (BONOMETTI et al, 2020). O COVID-19 possui características clínicas semelhantes às doenças autoimunes, pois ambas compartilham grandes reações imunes da patogênese. Acredita-se que o SARS-CoV-2 pode alterar a autotolerância e gerar respostas autoimunes através da reatividade cruzada com células hospedeiras (ASKANASE; KHALILI; BUYON, 2020). Conclusão: O Lúpus Eritematoso Sistêmico (LES) é uma doença que apresenta possível suscetibilidade a um quadro clínico grave do COVID-19, pois existem fatores epigenéticos que favorecem tal situação. Ademais, há relatos de pacientes os quais passaram a exibir sinais clínicos de lúpus desencadeados após a infecção pelo SARS-CoV-2.

Publicado

2021-04-22

Como Citar

Batista, B. de oliveira ., SANTOS, T. J. F. D. F. ., & GONÇALVES, H. M. . (2021). UMA ANÁLISE SOBRE A RELAÇÃO DA DOENÇA DO CORONAVÍRUS COM O LÚPUS ERITEMATOSO SISTÊMICO. Revista Multidisciplinar Em Saúde, 2(2), 65. https://doi.org/10.51161/rems/1017

Edição

v. 2 n. 2 (2021): Edição Especial: Anais de Eventos

Seção

Anais do Congresso Brasileiro de Imunologia On-line

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                         SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[1], , null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                      SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[4], , null, null, 500, 1) % line  194, file: SubmissionSearch.inc.php
                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php