EFEITO RENOPROTETOR DA CURCUMINA NA DOENÇA RENAL AGUDIZADA

Autores

  • Sheila Marques Fernandes Couto
  • Douglas Ikedo Machado
  • Carolina Condi
  • Beatriz de Almeida Brandi
  • Maria de Fátima Fernandes Vattimo

Palavras-chave:

Curcumina, Diabetes mellitus, Doença renal crônica, Lesão renal aguda, Isquemia e reperfusão

Resumo

Introdução: A doença renal crônica (DRC) e a doença renal diabética no diabetes mellitus (DM) aumentam a suscetibilidade à síndrome de isquemia e reperfusão (I/R). A I/R promove disfunção tubular renal, alteração hemodinâmica, inflamação e estresse oxidativo. A Curcumina é um ativo isolado da Curcuma longa L. que possui ação antioxidante e anti-inflamatória. Objetivo: Avaliar o efeito da Curcumina na função renal, hemodinâmica e estresse oxidativo renal de ratos com doença renal por DRC ou por DM submetidos a I/R. Material e métodos: Estudo experimental pré-clínico (Comitê de ética/CEUA-FMUSP: 1276/2019 e 1275/2019). Ratos Wistar, adultos, randomizados em oito grupos experimentais: SHAM (controle, n=5): simulação da DRC; CITRATO (controle veículo, n=5): administração de tampão citrato, i.v.; DRC (n=5): ablação de 5/6 da massa renal; DM (n=5): administração estreptozotocina, 65 mg/kg, diluída em citrato, i.v., 1 vez; DRC+I/R (n=5): DRC submetido ao clampeamento dos pedículos renais, 30 minutos-I/R; DRC+I/R+Curcumina (n=5): DRC seguido de administração de Curcumina 30mg/kg/dia, VO, 10 dias, e, após, o I/R; DM+I/R+CURCUMINA (n=5): DM, administração de Curcumina 30mg/kg/dia, v.o., 10 dias, e, após, o I/R. Os animais foram acompanhados por 28 dias. A função renal foi determinada pelo clearance de inulina e creatinina sérica, a hemodinâmica renal pelo fluxo sanguíneo renal e resistência vascular renal, o estresse oxidativo por mensuração dos peróxidos urinários e peroxidação lipídica. Análise estatística: ANOVA seguida de teste Tukey. Resultados: A Curcumina elevou o clearance de inulina e reduziu a creatinina sérica com diminuição da resistência vascular renal e aumento do fluxo sanguíneo renal, diminuição de peróxidos urinários e da peroxidação lipídica. Conclusão: O tratamento com Curcumina preservou a função dos animais com doença renal por DRC e DM agudizada pelo insulto da I/R promovendo melhora na hemodinâmica renal e redução do estresse oxidativo.

Publicado

2020-04-01

Como Citar

Marques Fernandes Couto, S. ., Ikedo Machado, D. ., Condi, C. ., de Almeida Brandi, B., & de Fátima Fernandes Vattimo, M. . (2020). EFEITO RENOPROTETOR DA CURCUMINA NA DOENÇA RENAL AGUDIZADA. Revista Multidisciplinar Em Saúde, 1(1), 21. Recuperado de https://editoraime.com.br/revistas/rems/article/view/106

Edição

v. 1 n. 1 (2020): Edição Especial: Anais do I Congresso Brasileiro de Ciências Farmacêuticas On-line

Seção

Anais de Evento

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

O conteúdo desta revista foi migrado para https://editoraintegrar.com.br

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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
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      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php

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                                                   SubmissionSearch._getMergedPhraseResults(Object:Journal, Array[4], null, null, null, 500, 1) % line  146, file: SubmissionSearch.inc.php
                                                SubmissionSearch._getMergedKeywordResults(Object:Journal, Array[3], null, null, null, 500, 1) % line  132, file: SubmissionSearch.inc.php
                                             SubmissionSearch._getMergedArray(Object:Journal, Array[1], null, null) % line  263, file: SubmissionSearch.inc.php
                                          SubmissionSearch.retrieveResults(Object:Request, Object:Journal, Array[1], null, null, null, Object:DBResultRange, Array[1]) % line   92, file: RecommendBySimilarityPlugin.inc.php
                                       RecommendBySimilarityPlugin.callbackTemplateArticlePageFooter(Templates::Article::Footer::PageFooter, Array[3]) % line  107, file: HookRegistry.inc.php
                                    HookRegistry.call(Templates::Article::Footer::PageFooter, Array[3]) % line 1267, file: PKPTemplateManager.inc.php
                                 PKPTemplateManager.smartyCallHook(Array[1], Object:Smarty_Internal_Template) % line   43, file: 42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php
                              content_6781613650b432_13896783(Object:Smarty_Internal_Template) % line  123, file: smarty_template_resource_base.php
                           Smarty_Template_Resource_Base.getRenderedTemplateCode(Object:Smarty_Internal_Template) % line  114, file: smarty_template_compiled.php
                        Smarty_Template_Compiled.render(Object:Smarty_Internal_Template) % line  216, file: smarty_internal_template.php
                     Smarty_Internal_Template.render(false, 1) % line  232, file: smarty_internal_templatebase.php
                  Smarty_Internal_TemplateBase._execute(Object:Smarty_Internal_Template, null, 42362804174f266c598cdb32c3208fc745b92101, null, 1) % line  134, file: smarty_internal_templatebase.php
               Smarty_Internal_TemplateBase.display(frontend/pages/article.tpl, null, 42362804174f266c598cdb32c3208fc745b92101, null) % line  924, file: PKPTemplateManager.inc.php
            PKPTemplateManager.display(frontend/pages/article.tpl) % line  292, file: ArticleHandler.inc.php
         ArticleHandler.view(Array[1], Object:Request) % line  391, file: PKPRouter.inc.php
      PKPRouter._authorizeInitializeAndCallRequest(Array[2], Object:Request, Array[1], false) % line  231, file: PKPPageRouter.inc.php
   PKPPageRouter.route(Object:Request) % line  143, file: Dispatcher.inc.php
Dispatcher.dispatch(Object:Request) % line  281, file: PKPApplication.inc.php
PKPApplication.execute() % line   68, file: index.php